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Background And Aim: Qualitative diagnosis of ulcerative colitis-associated neoplasia (UCAN) is crucial for surveillance colonoscopy in patients with ulcerative colitis (UC). Although the utility of magnifying endoscopy with narrow-band imaging (ME-NBI) in sporadic neoplasia diagnosis has been reported, its efficacy in UCAN remains unclear. This study aimed to evaluate the usefulness of ME-NBI for qualitative diagnosis of UCAN.

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Background And Aim: Optical diagnosis of superficial nonampullary duodenal epithelial tumors using white-light imaging (WLI) and/or narrow-band imaging with magnifying endoscopy (NBI-ME) is used to guide the treatment strategy and avoid biopsy-induced fibrosis. However, the effectiveness of this approach has not been elucidated. We conducted a systematic review and meta-analysis aiming to investigate the diagnostic yield between Vienna classification category 3 (VCL C3) and categories 4 or 5 (VCL C4/C5) using biopsy, WLI, NBI-ME, and WLI + NBI-ME.

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Article Synopsis
  • A 75-year-old woman was diagnosed with early-stage gastric cancer during an endoscopic examination, specifically a type 0-I carcinoma located on the middle part of her stomach.
  • During the procedure, small whitish structures called white globe appearances (WGAs) were observed near the cancer area, indicating potential subepithelial cancer spread despite the surface appearing flat and noncancerous.
  • Histopathology results confirmed the presence of cancer with significant lymphatic invasion, showing that the cancer had spread along the lymphatic vessels into surrounding tissues, which was likely responsible for the WGA characteristics seen during the endoscopy.
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Correlation between White Globe Appearance and Clinicopathologic Characteristics in Early Gastric Cancer.

Gut Liver

October 2024

Department of Internal Medicine, Pusan National University School of Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Background/aims: Magnifying endoscopy with narrow-band imaging (ME-NBI) enables the visualization of detailed microsurface (MS) and microvascular (MV) structures in the gastrointestinal tract. White globe appearance (WGA) is a small whitish lesion with a globular shape identified during ME-NBI for early gastric cancer (EGC). This study aimed to investigate the associations between WGA, clinicopathological characteristics, and other ME-NBI findings in patients with EGC.

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