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Persistent labial adhesions in a reproductive-age patient masquerading as urethrovaginal fistula.
BMJ Case Rep
January 2025
Obstetrics and gynaecology, All India Institute of Medical Sciences, New Delhi, Delhi, India.
Labial adhesion in a reproductive-age woman is a rare entity. A woman in her 30s presented with complaints of passage of urine and menstrual blood from the same opening since menarche. The patient underwent some corrective surgery for the same, but the symptoms did not resolve.
View Article and Find Full Text PDFBullous pyoderma gangrenosum revealing acute myeloid leukaemia.
BMJ Case Rep
January 2025
Dermatology Department, Cliniques universitaires Saint-Luc, Brussels, Belgium
We describe a man in his 60s presenting poor scar development following surgical treatment for popliteal aneurysm. The clinical features in a postoperative context and the poor clinical response to intravenous broad-spectrum antibiotics were highly suggestive of bullous pyoderma gangrenosum. Histology, with dense inflammatory infiltrate of neutrophils, subsequently confirmed the diagnosis and the response to systemic corticosteroids was rapid and complete.
View Article and Find Full Text PDFThe cellular response of lipopolysaccharide-induced inflammation in keratoconus human corneal fibroblasts to RB-PDT: Insights into cytokines, chemokines and related signaling pathways.
PLoS One
January 2025
Dr. Rolf M. Schwiete Center for Limbal Stem Cell and Aniridia Research, Saarland University, Homburg/Saar, Germany.
Purpose: Rose Bengal Photodynamic Therapy (RB-PDT) offers dual therapeutic benefits by enhancing corneal stiffness and providing antibacterial activity, presenting significant potential for patients with keratoconus complicated by keratitis. Our purpose was to assess the effect of rose bengal photodynamic therapy (RB-PDT) on the expression of pro-inflammatory cytokines and chemokines, as well as on extracellular matrix (ECM)-related molecules, in lipopolysaccharide (LPS)-induced inflammation of keratoconus human corneal fibroblasts (KC-HCFs). Additionally, the involvement of the mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways which are downstream of the Toll-like receptor 4 (TLR4) pathway were examined.
View Article and Find Full Text PDFTreatment of Surgical Scars with Fractional Carbon Dioxide (CO) Laser: A Randomized Controlled Trial.
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Department of Dermatology, The Second Affiliated Hospital of Wannan Medic-al College, Wuhu, Anhui, China.
The aim of this study was to compare the long-term effects of fractional carbon dioxide (CO) laser treatment with traditional therapy on surgical scars by analyzing and comparing observational indicators. A randomized controlled trial was conducted on 116 patients who received scar treatment in our hospital, of which 58 patients received fractional CO laser treatment, and 58 patients received injection treatment. The outcome measures comprised the Vancouver Scar Scale (VSS) and the Patient and Observer Scar Assessment Scale (POSAS).
View Article and Find Full Text PDFEffectiveness of gua sha with Masanggoubang oil in rats with chronic soft tissue injury.
Adv Clin Exp Med
January 2025
Acupuncture and Tuina College, Guizhou University of Traditional Chinese Medicine, Guiyang, China.
Background: Chronic soft tissue injury is characterized by sterile inflammation and pain. Gua sha with Masanggoubang oil (GSMO) treatment has been found to possess anti-inflammatory and analgesic effects.
Objectives: To explore the mechanism of GSMO in chronic soft tissue injuries.
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