AI Article Synopsis
- A chemical study of Waltheria indica's dichloromethane root extract isolated 10 quinoline alkaloids, including 8-deoxoantidesmone and waltheriones E-L, with new compounds characterized using various spectroscopic techniques.
- The chemical structures were confirmed through advanced spectroscopy methods, and absolute configurations were validated through comparison with theoretical ECD spectra.
- Some isolated compounds demonstrated strong antitrypanosomal activity against Trypanosoma cruzi, particularly compounds 4, 5, and 8, which showed low IC50 values, indicating effectiveness at minimal concentrations.
Article Abstract
Chemical investigation of the dichloromethane root extract of Waltheria indica led to the isolation and characterization of 10 quinoline alkaloids, namely, 8-deoxoantidesmone (1), waltheriones E-L (2-9), and antidesmone (10). Among these, compounds 2-9 have not yet been described in the literature. Their chemical structures were established by means of spectroscopic data interpretation including (1)H and (13)C NMR, HSQC, HMBC, COSY, and NOESY experiments and UV, IR, and HRESIMS. The absolute configurations of the compounds were established by comparison of experimental and TDDFT-calculated ECD spectra. In addition, the isolated constituents were evaluated for their in vitro antitrypanosomal activity. Compounds 4, 5, and 8 showed potent and selective growth inhibition toward Trypanosoma cruzi with IC50 values between 0.02 and 0.04 μM. Cytotoxicity for mouse skeletal L-6 cells was also determined for these compounds.
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