AI Article Synopsis
- CAP2 is proposed as a promising biomarker for hepatocellular carcinoma (HCC), particularly in early-stage patients who are AFP-negative.
- A study analyzed plasma levels of CAP2 and AFP in HCC patients, cirrhotic patients, and normal individuals, revealing CAP2 levels correlate better with tumor characteristics than AFP.
- CAP2 showed higher sensitivity in detecting HCC compared to AFP, making it a valuable tool for diagnosing HCC in situations where AFP may be lacking.
Article Abstract
Background And Objective: Cyclase-associated protein 2 (CAP2) has recently been suggested to be a candidate biomarker for hepatocellular carcinoma (HCC). We aim to investigate the application of CAP2 as a novel biomarker for HCC patients especially for those at early stage and are AFP-negative.
Methods: The CAP2 and AFP plasma levels were analyzed by enzyme-linked-immunosorbent assay in 86 HCC, 59 cirrhotic patients, and 30 normal individuals. Their correlation with HCC tumor behavior, disease stages, diagnostic sensitivity, specificity and accuracy were analyzed.
Results: The results showed that both CAP2 and AFP plasma levels in HCC patients were significantly elevated when compared to cirrhosis and controls. CAP2 levels correlate well with HCC patient's histological grade, clinical stage and tumor size, but not with patient's age, gender, hepatitis B virus infection status and plasma AFP level. CAP2 had better sensitivity as compared to AFP (82.6% vs 59.3%) for general HCC, and early stage of HCC patients (78.6% vs 40.4%). In addition, CAP2 is able to complement AFP to predict 82.9% of HCC in AFP-negative patients.
Conclusion: We suggest that CAP2 is a novel biomarker for HCC patient, this may be especially useful for detection of early stage HCC and when plasma AFP level is negative.
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| http://dx.doi.org/10.1016/j.clinre.2014.08.006 | DOI Listing |
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