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Olanzapine/Samidorphan Effects on Weight Gain: An Individual Patient Data Meta-Analysis of Phase 2 and 3 Randomized Double-Blind Studies.
J Clin Psychiatry
January 2025
Division of Pharmacotherapy and Translational Science, College of Pharmacy, University of Texas at Austin, San Antonio, Texas.
To evaluate weight change with a combination of olanzapine and samidorphan (OLZ/SAM) versus olanzapine by pooling data across clinical studies. This study was an individual patient data (IPD) meta-analysis of clinical trial data. EMBASE, MEDLINE, and PsycInfo were searched for randomized clinical trials (≥12 weeks) in adults with schizophrenia or bipolar I disorder in which weight change from baseline was the primary or secondary end point.
View Article and Find Full Text PDFLong-Term Safety, Tolerability, and Durability of Treatment Effect of Olanzapine and Samidorphan: Results of a 4-Year Open-Label Study.
J Clin Psychiatry
December 2024
Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New York.
Article Synopsis
- - The study evaluated the long-term safety, tolerability, and effect of olanzapine/samidorphan (OLZ/SAM) in patients with schizophrenia, schizophreniform disorder, or bipolar I disorder for up to 4 years, following the ENLIGHTEN clinical program.
- - Out of 524 enrolled patients, the majority had schizophrenia, and common adverse effects included weight gain, headache, and anxiety, with minimal changes in metabolic parameters over the treatment duration.
- - The treatment showed stable scores on the Clinical Global Impressions-Severity scale, indicating maintained symptom control and a long-term safety profile consistent with previous studies.
Pharmacological Treatment of Binge Eating Disorder and Frequent Comorbid Diseases.
CNS Drugs
September 2024
Lindner Center of HOPE, Mason, OH, USA.
Binge eating disorder (BED) is the most common specific eating disorder (ED). It is frequently associated with attention deficit hyperactivity disorder (ADHD), depression, bipolar disorder (BD), anxiety disorders, alcohol and nicotine use disorder, and obesity. The aim of this narrative review was to summarize the evidence for the pharmacological treatment of BED and its comorbid disorders.
View Article and Find Full Text PDFAlcohol Dependence Syndrome With Bipolar Affective Disorder and Hypomanic Current Episode: A Case Report.
Cureus
March 2024
Psychology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Studies have revealed that individuals with bipolar I and bipolar II have a past of substance abuse. The co-occurrence of bipolar disorder and alcoholism is frequent. Although various arguments have been put forward to explain the relationship between these disorders, it is still not fully understood.
View Article and Find Full Text PDFTreating Schizophrenia and Bipolar I Disorder in the Real-World Setting: Effectiveness and Safety of Olanzapine/Samidorphan Combination.
Prim Care Companion CNS Disord
April 2024
Department of Psychiatry, Weill Cornell Medical College, New York, New York.
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