AI Article Synopsis
- Stroke is a leading cause of death and disability in adults, and recent studies have linked specific genetic variants (rs556621 and rs11984041) to large artery atherosclerosis (LAA).
- Researchers examined these variants in a study of 733 LAA stroke patients from the Xinjiang Uyghur region of China, comparing them to a control group of 725 individuals.
- The findings showed that the rs556621 variant was significantly associated with LAA in the Uyghur population but not in the Han Chinese, while no notable differences were found for the rs11984041 variant in either group.
Article Abstract
Background: Stroke is one of the main causes of death and adult chronic disability. Recently, 2 independent genome-wide association studies reported that the genetic variants (rs556621 and rs11984041) are significantly associated with large artery atherosclerosis (LAA).
Methods: To determine whether these 2 variants are associated with the pathogenesis of LAA in stroke patients from the Xinjiang Uyghur autonomous region of China, both variants were evaluated in a series of 733 LAA stroke patients (434 Han and 299 Uyghur) and 725 age-, gender-, smoking-, alcohol habits- and ethnicity-matched controls (401 Han and 324 Uyghur).
Results: For rs556621, significant differences in genotypic and allelic distributions were observed between Uyghur patients and controls (P = .045 for genotypic distribution, P = .042 for allelic distribution) but not in the Chinese Han cohort (P > .05). No significant differences were found in genotypic and allele distributions between patients and controls for rs11984041 in either the Chinese Han or Uyghur cohort (P > .05).
Conclusions: The variant rs556621 but not rs11984041 may increase susceptibility of LAA stroke in the Xinjiang Uyghur population.
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| http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.06.015 | DOI Listing |
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Gene polymorphism of rs556621 but Not rs11984041 is associated with the risk of large artery atherosclerotic stroke in a Xinjiang Uyghur population.
J Stroke Cerebrovasc Dis
December 2015
Department of Neurology, the Third Xiangya Hospital, Central South University, Changsha, China. Electronic address:
Article Synopsis
- Stroke is a leading cause of death and disability in adults, and recent studies have linked specific genetic variants (rs556621 and rs11984041) to large artery atherosclerosis (LAA).
- Researchers examined these variants in a study of 733 LAA stroke patients from the Xinjiang Uyghur region of China, comparing them to a control group of 725 individuals.
- The findings showed that the rs556621 variant was significantly associated with LAA in the Uyghur population but not in the Han Chinese, while no notable differences were found for the rs11984041 variant in either group.
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