Allergenic and photosensitizing effects of organophosphorus pesticides (OPP) have been detected, as well as their destructive effect on the skin cell ultrastructure, on the body metabolism and enzymic systems, and the inhibitory effect on cholinesterase activity. Pesticide-induced changes in polyunsaturated fatty acids (PUFA) are significant in the mechanism of dermatoses development. The complex of treatment-and-prophylaxis measures includes regular dermatologic check-ups and limitation of the number of subjects handling OPP. Subjects in whom premorbid shifts have been detected, should be followed up. The therapy and prevention of the dermatoses developing as a result of exposure to pesticides may be effectively carried out with antioxidants, amino acids, vitamins, etc.; diets with the optimal PUFA-tocopherol ratio are advisable. Overalls with multiple protective physicochemical characteristics, filtering respirators and such are recommended.
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