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An ESR and DFT study of hydration of the 2'-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate. | LitMetric
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An ESR and DFT study of hydration of the 2'-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate.

Lidia Chomicz Alex Petrovici Ian Archbold Amitava Adhikary Anil Kumar Michael D Sevilla Janusz Rak

Chem Commun (Camb)

Department of Chemistry, University of Gdansk, 80-308 Gdansk, Poland.

Published: December 2014

The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2'-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4213299PMC
http://dx.doi.org/10.1039/c4cc07089eDOI Listing

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