AI Article Synopsis
- Hashimoto's thyroiditis (HT) is the most common autoimmune disease that often results in hypothyroidism, characterized by an immune response where T and B cells infiltrate the thyroid gland.
- There is a potential immunological connection between HT and papillary thyroid cancer (PTC), suggesting that both conditions can occur together.
- Three proposed mechanisms for this link include: preexisting autoimmunity triggering cancer due to inflammation, an immune response targeting existing tumor cells, and immune tolerance allowing cancer development despite autoimmunity.
Article Abstract
Hashimoto's thyroiditis (HT) is the most common autoimmune disease in humans frequently leading to hypothyroidism. HT is characterized by a cellular immune response with lymphatic infiltration of the thyroid gland by T and B cells, as well as by a humoral immune response leading to specific antibody production. The synchronous appearance of HT and papillary thyroid cancer (PTC) indicates an immunological link between the two entities. Three different pathomechanisms may be postulated, including preexisting autoimmunity leading to malignancy due to inflammation, immunity towards preexisiting tumor cells leading to specific autoimmunity, and immune tolerance leading to malignancy despite (auto)immunity. In this article we review data describing these potential mechanisms that might lead to the synchronous appearance of HT and PTC.
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| http://dx.doi.org/10.1016/j.tem.2014.09.001 | DOI Listing |
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