In March 2014, a person in their eighties who was diagnosed with extensive cellulitis due to toxigenic Corynebacterium ulcerans died from multiple organ failure. Environmental investigation also isolated C. ulcerans in biological samples from two stray cats in contact with the case. This finding provides further evidence that pets can carry toxigenic C. ulcerans and may be a source of the infection in humans.
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Non-toxigenic : beware the chronic ulcer.
Arch Dis Child
January 2025
Department of Infection and Immunity, Monash Children's Hospital, Clayton, Victoria, Australia.
We report a cluster of infections with genetically related toxigenic Corynebacterium diphtheriae linked to an outbreak among asylum seekers in Switzerland that subsequently affected patients without known exposure. This discovery highlights the importance of rapid, interdisciplinary outbreak investigations and regular vaccination status assessment, especially in elderly populations with waning immunity.
View Article and Find Full Text PDFToxin-producing strains are the etiological agents of the severe upper respiratory disease, diphtheria. A global phylogenetic analysis revealed that biotype gravis is particularly lethal as it produces diphtheria toxin and a range of other virulence factors, particularly when it encounters low levels of iron at sites of infection. To gain insight into how it colonizes its host, we have identified iron-dependent changes in the exoproteome and surfaceome of strain 1737 using a combination of whole-cell fractionation, intact cell surface proteolysis, and quantitative proteomics.
View Article and Find Full Text PDF[Two children in the Netherlands with a Corynebacterium diphtheriaeinfection].
Ned Tijdschr Geneeskd
October 2024
Wilhelmina Kinderziekenhuis, afd. Kinderinfectieziekten en Immunologie, Utrecht.
Infections with were virtually absent among the Dutch population due to vaccination, while in the first half of the 20th century, it was a significant cause of child mortality. However, due to imported infections resulting from migration from countries with low vaccination coverage, infections with are resurging. Concurrently, the vaccination rates among Dutch children are decreasing, elevating the risk of outbreaks.
View Article and Find Full Text PDFGenotypic and phenotypic characterization of the first Latin America isolates of Corynebacterium rouxii, a recently described member of the Corynebacterium diphtheriae complex reported in Europe.
Braz J Microbiol
December 2024
Operational Technical Nucleus, Hermes Pardini Institute, Microbiology, Minas Gerais, Brazil.
Article Synopsis
- The genus Corynebacterium includes several species with epidemic potential that can cause serious diseases, making accurate identification crucial for public health.
- Recent discoveries have complicated traditional microbiological methods, necessitating advanced techniques like DNA sequencing for reliable identification and epidemiological monitoring.
- In a study, two bacterial strains from a cat were identified as Corynebacterium diphtheriae, but further analysis revealed they were actually non-toxigenic C. rouxii, marking the first report of this species in Latin America.
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