AI Article Synopsis
- This study investigates how nitric oxide affects placental structure and macrophage activity during normal pregnancy in albino rats.
- The rats were divided into three groups: one with normal pregnancies, one given sodium nitrate, and another injected with a nitric oxide synthesis inhibitor.
- Findings showed that both sodium nitrite and the inhibitor caused structural changes in the placenta, indicating circulation issues and potential damage.
- The activity of placental macrophages differed significantly between the groups, highlighting contrasting effects of nitric oxide levels.
Article Abstract
Objective: To study the effects of nitric oxide (NO) on the morphology of the placenta and the activity of placental macrophages during uncomplicated pregnancy in albino rats.
Material And Methods: The animals were divided into 3 groups. Group included animals with uncomplicated pregnancy; Group 2 was given drinking water containing 0.2% sodium nitrate on day 1 of pregnancy; Group 3 was intramuscularly injected with the NO synthesis inhibitor Nw-nitro-L-arginine methyl ester (L-NAME) in a dose of 10 mg/kg on day 1 of pregnancy. The central portion of hematoxylin- and eosin-stained placentas was morphologically examined. The activity of placental macrophages was assessed by incubating them with autologous erythrocytes.
Results: Pathological examinations of the placentas reveal that when sodium nitrite and L-NAME enter the animal body, structural changes in the placental show that there are maternal and placental circulatory disorders concurrent with dystrophic and destructive processes.
Conclusion: The activity of placental macrophages in the examined groups is diametrically opposite.
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