A long-term observation for 12 years revealed a tendency to stabilization of localization of tuberculous infection foci in rural areas and their main concentration in large villages. In such villages 82.7 per cent of new cases of tuberculosis and 80.3 per cent of new cases of tuberculous infection were recorded. The tension of the epidemiological situation with respect to tuberculosis in rural areas directly depended on the number of tubercle bacilli carriers living in such areas. It was maintained by three factors: migration of the bacilli carriers, the number of new cases of bacillary tuberculosis of the lungs and the results of their therapy. Among persons having family contacts with tubercle bacilli carriers, the incidence of pulmonary tuberculosis was 12.4 and 40.6 times higher than that resulting from professional and village contacts, respectively. A differential approach to organization of anti-epidemiological measures, early detection and prophylaxis of tuberculosis in rural areas is proposed.
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Infect Dis Ther
January 2025
Christian Medical College, Vellore, Tamil Nadu, India.
Tuberculous meningitis (TBM) disables more than a third of its sufferers. Recent research has focused on optimizing the antitubercular regimen, mainly by increasing the dosage of rifampicin. However, pyrazinamide, with higher penetration into the central nervous system, is generally overlooked.
View Article and Find Full Text PDFAnn Hematol
January 2025
Division of Hematology & Medical Oncology, Department of Internal Medicine, Hanyang University Medical Centre, Hanyang University College of Medicine, Seoul, Republic of Korea.
Tuberculosis (TB) is associated with chronic inflammation, which has been implicated in the pathogenesis of various malignancies, including lung cancer. However, the relationship between TB and hematological malignancies like lymphoma remains less understood. This study aimed to investigate risks of incident malignant lymphoma according to previous TB infection in a large prospective cohort of 347,204 individuals.
View Article and Find Full Text PDFXi Bao Yu Fen Zi Mian Yi Xue Za Zhi
December 2024
Department of Infection and Immunology, Changsha First Hospital, Changsha 410005, China.
Objective To clarify the mechanism that HIV infection mediates mitochondrial damage of CD4 T lymphocytes (CD4 T cells) through mitogen-activated protein kinase (MAPK) pathway. Methods From October 1st, 2022 to March 31st, 2023, 47 HIV-infected people who received antiretroviral therapy (ART) for 4 years were recruited, including 22 immune non-responders (INR) and 25 responders (IR); and 26 sex and age-matched control participants (HC) who were negative for HCV, HBV, and HIV infections. The immune parameters were analyzed by flow cytometry.
View Article and Find Full Text PDFJ Pediatric Infect Dis Soc
January 2025
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, USA.
Introduction: Identifying tuberculosis infection (TBI) using interferon-gamma release assays (IGRAs) is a primary component of clinical and public health efforts to prevent pediatric tuberculosis. Pediatric data comparing the two IGRAs in the United States are very limited. We compared the performance of the two IGRAs among a large pediatric cohort tested for TBI and assessed whether discordance might be due to quantitative results close to test cut-off values.
View Article and Find Full Text PDFJ Med Chem
January 2025
Helmholtz Institute for Pharmaceutical Research (HIPS)-Helmholtz Centre for Infection Research (HZI), Saar-land University, Campus E8.1, 66123Saarbrücken, Germany.
Antimicrobial resistance (AMR) and herbicide resistance pose threats to society, necessitating novel anti-infectives and herbicides exploiting untapped modes of action like inhibition of IspD, the third enzyme in the MEP pathway. The MEP pathway is essential for a wide variety of human pathogens, including , , and as well as plants. Within the current perspective, we focused our attention on the third enzyme in this pathway, IspD, offering a comprehensive summary of the reported modes of inhibition and common trends, with the goal to inspire future research dedicated to this underexplored target.
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