DNA double-strand breaks are repaired by nonhomologous end-joining (NHEJ) and homologous recombination (HR). Disrupting the balance between these pathways results in toxic chromosomal rearrangements. Several recent studies are revealing that dynamic changes in chromatin conformation can regulate DNA repair pathway choice both spatially and temporally.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4254157 | PMC |
| http://dx.doi.org/10.1016/j.tcb.2014.09.004 | DOI Listing |
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