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Pentraxin 3 promotes microglial M2 polarization and excitatory synapse formation in the hippocampus in depression.
Int Immunopharmacol
December 2024
Department of Radiology, Affiliated People's Hospital of Jiangsu University, Zhenjiang 212001, China. Electronic address:
Depression is a prevalent mental illness that significantly impairs individuals' overall quality of life and physical well-being. However, the pathological mechanisms of depression remain unclear, and effective treatment strategies are urgently needed. Pentraxin 3 (PTX3), a long pentraxin protein, plays a significant role in various pathological conditions, including infections, immune responses, and tissue repair.
View Article and Find Full Text PDFDisulfide bonds-driven assembly and structural complexity of PTX3: High-resolution structures insights into multimeric architecture.
Int J Biol Macromol
December 2024
Southern University of Science and Technology, Shenzhen 518055, China; Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China. Electronic address:
Pentraxin-3 (PTX3) is a multifunctional pattern-recognition molecule that is essential for immune defense, pathogen recognition, and complement activation. PTX3 is stored as a monomer in neutrophil granules, and assembles into higher-order oligomers upon immune activation, thereby enhancing its antimicrobial function. The mechanism underlying this assembly remains elusive.
View Article and Find Full Text PDFPTX3-assembled pericellular hyaluronan matrix enhances endochondral ossification during fracture healing and heterotopic ossification.
Bone
December 2024
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China. Electronic address:
Endochondral ossification (EO) is a pivotal process during fracture healing and traumatic heterotopic ossification (HO), involving the cartilaginous matrix synthesis and mineralization. Unlike the extracellular matrix, the hyaluronan (HA)-rich pericellular matrix (PCM) directly envelops chondrocytes, serving as the frontline for extracellular signal reception and undergoing dynamic remodeling. Pentraxin 3 (PTX3), a secreted glycoprotein, facilitates HA matrix assembly and remodeling.
View Article and Find Full Text PDFPTX 3 (pentraxin3) is associated with lung function among people with stable-stage smoking-related chronic obstructive pulmonary disease.
Heart Lung
December 2024
Department of Respiratory and Critical Care Medicine, Mingguang People's Hospital, no.379 Mingguang Avenue, Mingguang City, Chuzhou City, 239400 Anhui Province, PR China. Electronic address:
Background: Chronic obstructive pulmonary disease (COPD) is a prevalent chronic respiratory illness. Pentraxin-3 (PTX3) is abnormally elevated in the plasma of patients with acute exacerbation of COPD. However, the role and significance of PTX3 in the clinical diagnosis of COPD remain unclear.
View Article and Find Full Text PDFHydroxytyrosol's Protective Effect Through Podocalyxin and Pentraxin-3 in Kidney Damage Resulting From Corn Syrup Administration.
Cureus
November 2024
Department of Histology and Embryology, Firat University Faculty of Medicine, Elâzığ, TUR.
Introduction: In this study, we aimed to investigate whether hydroxytyrosol (HT) has a protective effect on corn syrup-induced kidney damage in rats and the role of podocalyxin (PCX) and pentraxin-3 (PTX3) in this possible effect.
Methods: Rats were divided into four groups with six rats in each group: 1) control, 2) HT, 3) corn syrup, and 4) corn syrup + HT. Rats were given 30% corn syrup added to their drinking water for six weeks.
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