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Novel factors of cisplatin resistance in epithelial ovarian tumours.
Adv Med Sci
January 2025
Department of Medical Biology, Faculty of Medicine, Pavol Jozef Šafárik University, Košice, Slovak Republic. Electronic address:
Ovarian tumours are these days one of the biggest oncogynecological problems. In addition to surgery, the treatment of ovarian cancer includes also chemotherapy in which platinum preparations are one of the most used chemotherapeutic drugs. The principle of antineoplastic effects of cisplatin (cis-diamminedichloroplatinum(II), CDDP) is its binding to the DNA and the formation of adducts.
View Article and Find Full Text PDFCellular senescence induced by down-regulation of correlates with exon skipping of mitochondrial-related gene .
Life Med
April 2024
Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai 200438, China.
As the most prevalent type of alternative splicing in animal cells, exon skipping plays an important role in expanding the diversity of transcriptome and proteome, thereby participating in the regulation of diverse physiological and pathological processes such as development, aging, and cancer. Cellular senescence serving as an anti-cancer mechanism could also contribute to individual aging. Although the dynamic changes of exon skipping during cellular senescence were revealed, its biological consequence and upstream regulator remain poorly understood.
View Article and Find Full Text PDFMitochondrial retrograde signaling (MRS) pathways relay the functional status of mitochondria to elicit homeostatic or adaptive changes in nuclear gene expression. Budding yeast have "intergenomic signaling" pathways that sense the amount of mitochondrial DNA (mtDNA) independently of oxidative phosphorylation (OXPHOS), the primary function of genes encoded by mtDNA. However, MRS pathways that sense the amount of mtDNA in mammalian cells remain poorly understood.
View Article and Find Full Text PDFantigen induced innate immune memory features mitochondrial biogenesis and can be inhibited by ovarian produced hormones.
bioRxiv
January 2025
Department of Pathology, Division of Microbiology and Immunology, University of Utah, Salt Lake City UT, 84112.
We have previously identified that infection induces a unique form of myeloid training that protects male but not female mice from high fat diet induced disease. Here we demonstrate that ovarian derived hormones account for this sex specific difference. Ovariectomy of females prior to infection permits metabolic reprogramming of the myeloid lineage, with BMDM exhibiting carbon source flexibility for cellular respiration, and mice protected from systemic metabolic disease.
View Article and Find Full Text PDFEpigenetic Threads of Neurodegeneration: TFAM's Intricate Role in Mitochondrial Transcription.
CNS Neurol Disord Drug Targets
January 2025
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Mysuru 570015. JSS Academy of Higher Education and Research, Mysuru, Karnataka, India.
There is a myriad of activities that involve mitochondria that are crucial for maintaining cellular equilibrium and genetic stability. In the pathophysiology of neurodegenerative illnesses, mitochondrial transcription influences mitochondrial equilibrium, which in turn affects their biogenesis and integrity. Among the crucial proteins for keeping the genome in optimal repair is mitochondrial transcription factor A, more commonly termed TFAM.
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