Lymphomas are malignant neoplasms arising from lymphocytes B cell or T cell that affects mainly lymph nodes, spleen and other non hematopoietic tissues. They are classified as Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Diffuse large B-cell lymphoma (DLBL) is the most common variant of non-Hodgkin's lymphomas and frequently involves extranodal sites. In the oral soft tissues lesions can occur as hard and diffuse tumors involving oral vestibule, gums and posterior region of the hard palate. Most lymphomas, including DLBL arise from B cells are characterized by diffuse population of large cells with cleaved or non cleaved oval nuclei. Both histopathlogical and immunohistochemical (IHC) analysis were strongly advisable for proper management and prognosis. We hereby report a rare case of Diffuse large B-cell variant of non-Hodgkin's lymphoma in a male patient of age 50yrs in left upper buccal vestibule.
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http://dx.doi.org/10.7860/JCDR/2014/8396.4740 | DOI Listing |
BMJ Case Rep
March 2025
Hematology/Oncology, Walter Reed National Military Medical Center, Bethesda, Maryland, USA.
Here, we present the case of a young man active-duty service member diagnosed with stage IE penile diffuse large B-cell lymphoma (DLBCL), germinal centre B-cell (GCB) subtype. Primary penile DLBCL is an exceptionally rare condition, with fewer than 30 cases reported in the medical literature. Notably, this patient is significantly younger than the typical demographic, as extranodal DLBCL affecting the penis usually occurs in elderly men, with a median age of 69 years at diagnosis.
View Article and Find Full Text PDFMixed neoplasms represent a big family of complex tumors that consist of more than one neoplastic tissue. Mixed tumors are categorized into collision, composite, carcinosarcomas, and amphicrine tumors. Case Report: Hereinafter, we describe a case of a collision tumor composed of mantle cell lymphoma and mucinous adenocarcinoma located in the ascending colon in a 63-year-old man.
View Article and Find Full Text PDFRecenti Prog Med
March 2025
Uoc Ctmo Grande Ospedale Metropolitano (Gom) "Bianchi-Melacrino-Morelli", Reggio Calabria.
Introduction: Mantle cell lymphoma (MCL) is one of the rarest forms of non-Hodgkin's lymphoma that mainly affects adults around 65 years of age or older, and is diagnosed when the disease has already reached a fairly advanced stage. Partly for this reason, but mainly because of the very characteristics of this rare form of lymphoma, the prognosis is often poor. In most cases, the disease recurs after a period of remission achieved with I-line.
View Article and Find Full Text PDFRecenti Prog Med
March 2025
SC Ematologia, Aou Città della Salute e della Scienza di Torino.
Introduction: Relapsed or refractory (R/R) mantle cell lymphoma (MCL) represent a setting at unfavourable prognosis. Chimeric antigen receptor T-cells (CAR-T) are recently introduced in clinical practice as a new therapeutic option for this setting.
Clinical Case: 61-year-old man with MCL pleomorphic variant, TP53 mutated with high risk MIPI-c early relapsed after frontline immunochemotherapy and ibrutinib.
Recenti Prog Med
March 2025
Unità operativa di ematologia, Asst Spedali Civili di Brescia.
Mantle cell lymphoma is a rare and aggressive hematologic malignancy characterized by frequent relapses and poor prognosis. Recently, the approval of CAR-T cell therapy has transformed the treatment landscape for relapsed/refractory patients. We report the case of a 52-year-old patient with mantle cell lymphoma who experienced multiple disease relapses.
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