We are reporting a clinical case of a 78-year-old male who had oppressive chest pain at rest, which regressed with the intake of sublingual nitrates. Coronary angiography showed a chronic total occlusion (CTO) of the left anterior descending (LAD) artery, a normal circumflex, a hypoplasic right coronary artery and a Cardiac Magnetic Resonance showing vital tissue in anterior wall. During the procedure of CTO-PCI on LAD, patient developed multiple and contemporary coronary thrombosis in spite of low platelet reactivity, which was assessed by using Multiplate. A manual thrombectomy was performed with a good final result only after drug eluting stents (DES) implantation.
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http://dx.doi.org/10.7860/JCDR/2014/7811.4657 | DOI Listing |
Neural Comput
January 2025
Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, 200437, China
Spiking neural networks (SNNs) have attracted significant interest in the development of brain-inspired computing systems due to their energy efficiency and similarities to biological information processing. In contrast to continuous-valued artificial neural networks, which produce results in a single step, SNNs require multiple steps during inference to achieve a desired accuracy level, resulting in a burden in real-time response and energy efficiency. Inspired by the tradeoff between speed and accuracy in human and animal decision-making processes, which exhibit correlations among reaction times, task complexity, and decision confidence, an inquiry emerges regarding how an SNN model can benefit by implementing these attributes.
View Article and Find Full Text PDFFront Microbiol
December 2024
Department of Soil and Water Systems, University of Idaho, Moscow, ID, United States.
Soil microbial communities are vulnerable to anthropogenic disturbances such as climate change and land management decisions, thus altering microbially-mediated ecosystem functions. Increasingly, multiple stressors are considered in investigations of ecological response to disturbances. Typically, these investigations involve concurrent stressors.
View Article and Find Full Text PDFExp Mol Med
January 2025
Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Altruism, an act of benefiting others at a cost to the self, challenges our understanding of evolution. This Perspective delves into the importance of altruism in cancer cells and its implications for therapy. Against the backdrop of existing knowledge on various social organisms found in nature, we explore the mechanisms underlying the manifestation of altruism within breast tumors, revealing a complex interplay of seemingly counteracting cancer signaling pathways and processes that orchestrate the delicate balance between cost and benefit underlying altruistic cooperation.
View Article and Find Full Text PDFMedicina (Kaunas)
December 2024
School of Medicine, University of Zagreb, 10000 Zagreb, Croatia.
Despite being one of the most common infectious diseases, urinary tract infections (UTIs) still represent a challenge for clinicians to diagnose and treat, especially in the era of growing antibiotic resistance among uropathogenic bacteria. Recent studies investigating the pathophysiology of UTIs have discovered the prominent role of antimicrobial peptides in the urinary tract defense system. Cathelicidin is an evolutionary conserved antimicrobial peptide encoded by one single gene in humans.
View Article and Find Full Text PDFInt J Environ Res Public Health
December 2024
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK.
The objective of this study was to synthesise evidence assessing the effectiveness of workplace-based interventions that promote self-management of multiple long-term conditions or disabilities, e.g., type I and II diabetes, asthma, musculoskeletal injury/disorder, cancer, and mental ill-health.
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