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The immune response modulated by inoculation of commensal bacteria at birth impacts the gut microbiota and prevents colonization.
Gut Microbes
December 2025
ISP, INRAE, Université François Rabelais de Tours, Nouzilly, France.
Super- and low-shedding phenomena have been observed in genetically homogeneous hosts infected by a single bacterial strain. To decipher the mechanisms underlying these phenotypes, we conducted an experiment with chicks infected with Enteritidis in a non-sterile isolator, which prevents bacterial transmission between animals while allowing the development of the gut microbiota. We investigated the impact of four commensal bacteria called Mix4, inoculated at hatching, on chicken systemic immune response and intestinal microbiota composition and functions, before and after infection.
View Article and Find Full Text PDFSalmonellosis-Induced Pericarditis and Pericardial Effusion: A Case Report and Literature Review.
Cureus
February 2025
Nephrology, NewYork-Presbyterian, New York, USA.
While salmonellosis is commonly thought to predominantly impact the gastrointestinal system, bacteremia and localized extraintestinal infections such as meningitis, empyema, and pericarditis can develop, particularly in immunocompromised individuals. Here, we present a case of a 69-year-old with multiple comorbidities, who presented to the emergency department with dyspnea and hemodynamics instability in the form of hypoxia and hypotension and was found to have moderate pericardial effusion without echocardiographic signs of tamponade. The ischemic workup was unrevealing, and further infectious workups, including pericardial tissue biopsy and pericardial fluid culture, showed growth in groups C and D.
View Article and Find Full Text PDFTreatment-Related Mechanisms of Tibetan Medicine (TC) Aqueous Extract Against Mouse Gastroenteritis Caused by Yak-Origin Determined Using Intestinal Microbiome Analysis and Metabolomics.
Animals (Basel)
March 2025
College of Animal Science, Tibet Agricultural and Animal Husbandry University, Nyingchi 860000, China.
This study aimed to evaluate the therapeutic effect of (TC) on Tibetan yak-origin -induced diarrhea and dysentery in mice. The levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, and TNF-α), anti-inflammatory cytokines (IL-4 and IL-10), and the oxidative stress markers malondialdehyde (MDA), superoxide dismutase (T-SOD), total antioxidant capacity (T-AOC), reduced glutathione (GSH-PX), and catalase (CAT) in the serum of mice were measured using ELISA kits. Using microbial diversity sequencing and non-targeted metabolomics detection techniques, the relevant mechanisms of TC treatment in a mouse infection model were evaluated.
View Article and Find Full Text PDFInvasive Salmonella Typhimurium Colonizes Gallbladder and Contributes to Gallbladder Carcinogenesis through Activation of Host Epigenetic Modulator KDM6B.
Cancer Lett
March 2025
Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi-110608, India. Electronic address:
Gallbladder stones alone do not explain the risk of gallbladder cancer (GBC) as the sole etiological factor. Chronic microbial infection, particularly Salmonella, has been implicated in GB carcinogenesis, but its causative role and the underlying mechanisms are largely unknown. We studied gut and gallbladder tissue microbiome through targeted metagenomics to identify pathogenic bacteria in GBC.
View Article and Find Full Text PDFEvaluation of the virulence characteristics of ST11 Salmonella enterica from different sources using a 2D cell model.
Int J Food Microbiol
March 2025
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China. Electronic address:
This study aimed to evaluate the virulence characteristics of ST11 Salmonella enterica from various sources and explore its pathogenic mechanisms and the molecular basis of antimicrobial resistance. In total, 20 Salmonella isolates collected between 2017 and 2022 from environmental, animal, clinical, and food sources were analyzed. Comprehensive investigations were conducted using whole-genome sequencing, bioinformatic analysis, broth microdilution methods, a two-dimensional (2D) cell model (Caco-2 cells), and a Galleria mellonella infection model.
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