AI Article Synopsis
Article Abstract
Background: High frequency oscillations (HFOs, 80-500 Hz) are EEG biomarkers for epileptogenic areas. HFOs are also indicators of disease activity as HFO rates increase after reduction of antiepileptic medication. Electrical stimulation (ES) can be used for diagnostic purposes as well as therapy in patients with refractory epilepsy. This study investigates the occurrence and changes of HFOs during ES in patients with refractory epilepsy.
Objective: Analysis of the effects of ES using intracranial ES on the occurrence of epileptic HFOs.
Methods: Patients underwent ES for diagnostic purposes. Ripples (80-200 Hz) and fast ripples (200-500 Hz) were visually marked in a baseline EEG segment prior to ES, after each period of ES as well as after the end of ES. In patients in whom ES triggered a seizure a pre- and postictal segment was marked. Rates of HFOs were compared for the different time periods using a Spearman's correlation and Wilcoxon rank sum test (p<0.05).
Results: 12 patients with 911 EEG channels were analyzed. Ripple (r=-0.42, p<0.001) as well as fast ripple (r=-0.21, p<0.001) rates decreased significantly over the course of stimulation. This phenomenon was not focal over the seizure onset or neighboring contacts but even observed over distant contacts.
Conclusions: ES resulted in a gradual decrease of HFO-Rates over time. The decrease of HFOs was not limited to SOZ areas. If HFOs are considered as markers of disease activity the reduction in HFO-rates as a result of intracranial ES has to be interpreted as a reduction of disease activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.eplepsyres.2014.09.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of Osborne's Ligament Suspension and Ulnar Nerve Anterior Transposition in Conjunction with Transcutaneous Electrical Nerve Stimulation for Managing Cubital Tunnel Syndrome: A Retrospective Study.
Ann Ital Chir
December 2024
Department of Hand & Foot and Reconstructive Microsurgery, The First Hospital of Qinhuangdao, 066000 Qinhuangdao, Hebei, China.
Aim: To explore the effectiveness and safety of Osborne's ligament suspension and ulnar nerve anterior transposition (OLSUNAT) in conjunction with transcutaneous electrical nerve stimulation (TENS) for managing cubital tunnel syndrome (CTS).
Methods: A total of 116 individuals diagnosed with CTS who underwent OLSUNAT in our hospital between October 2020 and December 2023 were retrospectively selected. They were divided into a treatment group (62 cases) and a control group (54 cases) based on whether they received subsequent TENS.
Transcutaneous Electrical Nerve Stimulation for Prevention and Treatment of Post-Herpetic Neuralgia: A Narrative Review.
Cureus
November 2024
Department of Pain Medicine, Fondazione Paolo Procacci, Rome, ITA.
The present investigation evaluated transcutaneous electrical nerve stimulation (TENS) for the non-pharmacological treatment of post-herpetic neuralgia (PHN). PHN is the most common complication of the Herpes Zoster virus, affecting one in every five patients with shingles, and presents as intense neuropathic pain that can persist for 90 days or longer after the initial onset of symptoms. Current pharmacological treatment options are mainly limited to symptom management, including oral medications such as tricyclic antidepressants and gabapentinoid preparations, as well as topical options such as lidocaine or capsaicin.
View Article and Find Full Text PDFSpectral and coupling characteristics of somatosensory cortex and centromedian thalamus differentiate between pre- and interictal 5-9 Hz oscillations in a genetic rat model of absence epilepsy.
Neurobiol Dis
December 2024
Institute of Physiology I, Münster University, Münster, Germany. Electronic address:
Spike-wave-discharges (SWD) are the electrophysiological hallmark of absence epilepsy. SWD are generated in the thalamo-cortical network and a seizure onset zone was identified in the somatosensory cortex (S1). We have shown before that inhibition of the centromedian thalamic nucleus (CM) in GAERS rats resulted in a selective suppression of the spike component while rhythmic cortical 5-9 Hz oscillations remained present.
View Article and Find Full Text PDFNeurohistopathological findings of the brain parenchyma after long-term deep brain stimulation: Case series and systematic literature review.
Parkinsonism Relat Disord
December 2024
Department of Neurosurgery, University of Iowa, Iowa City, IA, United States. Electronic address:
Introduction: Efficacy of deep brain stimulation (DBS) is established for several movement and psychiatric disorders. However, the mechanism of action and local tissue changes are incompletely described. We describe neurohistopathological findings of 9 patients who underwent DBS for parkinsonism and performed a systematic literature review on postmortem pathologic reports post-DBS.
View Article and Find Full Text PDFReconfigurations of dynamic functional network connectivity after 1HZ repetitive transcranial magnetic stimulation in insomnia disorder.
Sleep Med
December 2024
School of Automation and Electrical Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, 014010, China. Electronic address:
Aims: The objective of the current study was to investigate the dynamic functional connectivity among large-scale brain networks in patients with insomnia, and to assess the efficacy of repetitive transcranial magnetic stimulation (rTMS) treatment in these individuals.
Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data from 62 insomnia patients and 69 healthy controls were used to compare differences in dynamic functional connectivity between the two groups. A total of 26 insomnia patients underwent rTMS for four weeks.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!