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Total functioning capacity scale in Huntington's disease: natural course over time.
J Neurol
January 2025
LUMC Department of Neurology, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Background And Objectives: The total functioning capacity (TFC) assessment has been integral to Huntington's disease (HD) research and clinical trials, measuring disease stage and progression. This study investigates the natural progression of function in HD, focusing on changes in TFC scores related to age and CAG-repeat length, and evaluates TFC's strengths and weaknesses in longitudinal studies.
Methods: Using Enroll-HD platform's clinical dataset version 5, including Registry-3, we analysed data from 21,079 participants, with 16,083 having an expanded CAG repeat.
Impact of skeletal muscle mass of the trunk and extremities on standing spine parameters before and after surgery for adult spinal deformity with a minimum 2-year follow-up.
Eur Spine J
January 2025
Department of Orthopaedics, University of Yamanashi, 1110, Shimokato, Chuo, Yamanashi, 409-3898, Japan.
Purpose: The effect of skeletal muscle mass of the trunk and extremities on sagittal imbalance of the spine before and after surgery for adult spinal deformity (ASD) has not been elucidated. The purpose of this study was to examine the correlation between reduced skeletal muscle mass of the trunk and extremities, as well as spinopelvic parameters, preoperatively, postoperatively and at least 2 years after surgery for ASD.
Methods: This retrospective observational study included 140 consecutive patients who had undergone surgery for ASD and were followed-up for at least 2 years and whose skeletal muscle mass could be measured preoperatively using whole-body dual-energy X-ray absorptiometry.
Impact of ions, pH and the nature of substrate on the structure and activity of a robust single-stranded DNA binding (SSB)-like protein from Phi11.
Arch Microbiol
January 2025
Department of Biological Sciences, Birla Institute of Technology and Science, Pilani, K K Birla Goa Campus, NH17B, Zuarinagar, Goa, 403726, India.
The gene gp13 in bacteriophage Phi11 has been annotated as a Single-Stranded DNA binding protein (SSB protein, GenBank accession no. NC_004615.1).
View Article and Find Full Text PDFClassical cell cycle kinase limits tubulin polyglutamylation and cilium stability.
J Cell Biol
February 2025
Department of Molecular and Cell Biology, University of California, Merced, Merced, CA, USA.
Tubulin polyglutamylation is essential for maintaining cilium stability and function, and defective tubulin polyglutamylation is associated with ciliopathies. However, the regulatory mechanism underlying proper axonemal polyglutamylation remains unclear. He et al.
View Article and Find Full Text PDFThe role of skin microbiota in lichen planus from a Mendelian randomization perspective.
Arch Dermatol Res
January 2025
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Lichen planus is a chronic skin lesion characterized by pruritic violaceous papules, which has a high risk of morbidity. Skin microbiota plays an important role in the maintenance of cutaneous mucosal barrier and human health and immune homeostasis. Studies have shown that skin microbiota may play a role in the pathogenesis of lichen planus, but it is not yet clear.
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