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Introduction: Limited research is available regarding recommendations about which drug allergy alerts (DAAs) in clinical decision support (CDS) systems should interrupt provider workflow. The objective was to evaluate the frequency of penicillin and cephalosporin DAA overrides at two institutions. A secondary objective was to redesign DAAs using a new tiered alerting system based on patient factors.
View Article and Find Full Text PDFEpidemiology and Triggers of Severe Perioperative Anaphylaxis: Comment.
J Cardiothorac Vasc Anesth
January 2025
University of Antwerp, Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology, Infla-Med Centre of Excellence, Immunology, Allergology, Rheumatology, Antwerp University Hospital, Antwerp Belgium; Department of Immunology and Allergology, AZ Jan Palfijn Ghent, Ghent, Belgium.
Oral immunotherapy is proposed as the only active intervention to modify allergies and decrease the risk of severe reactions. However, it is crucial to note that oral immunotherapy still presents a notable failure rate and potential for severe, life-threatening outcomes. Notably, patients who discontinue oral immunotherapy may face an increased risk of fatal reactions.
View Article and Find Full Text PDFLong-term antibiotic prophylaxis for prevention of rheumatic fever recurrence and progression to rheumatic heart disease.
Cochrane Database Syst Rev
September 2024
Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.
Background: Rheumatic fever is a non-suppurative, inflammatory sequela of group A Streptococcus pharyngitis that can occur at two to four weeks after infection. Following an episode of rheumatic fever, there is a risk of developing rheumatic heart disease (RHD) later in life that carries significant risk of morbidity and mortality. RHD remains the largest global cause of cardiovascular disease in the young (age < 25 years).
View Article and Find Full Text PDFSerum tryptase changes in children with suspected perioperative hypersensitivity. Comment on 2024; 9: 100254.
BJA Open
December 2024
Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, Australia.
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