Background: It is believed that treatment with low temperature can reduce pain perception in chronic pain patients, including chronic low back pain patients.

Aim: To evaluate the effects of a two-week repeated intervention of -67 °C cryo-chamber in patients with chronic low back pain.

Design: A prospective randomized double blind study design.

Setting: Hospital-based outpatients department

Population: Outpatients with chronic low back pain.

Methods: Comparing intervention group (-67 °C) with higher temperature (-5 °C) which was supposed as a control group in a cryo-chamber.

Results: Similar effectiveness in pain reduction in both intervention and control groups

Conclusion: Cryochamber therapy with -67 °C is not superior to (sham cryo chamber) with -5 °C.

Clinical Rehabilitation Impact: Cryo chambers therapy show positive effect by improving pain. For the treatment, -5 °C seems to be sufficient for these patients.

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