Break on through to the other 1.

Cell Metab

College of Arts and Sciences, Chemistry Department, Indiana University Bloomington, 800 East Kirkwood Avenue, Bloomington, IN 47405-7102, USA.

Published: October 2014

Although discovered in 1974, FGF1 was previously unrealized to have a role in metabolism. Suh et al. (2014) now report impressive pharmacological outcomes of FGF1 therapy in mice that imply this protein is an important metabolic regulator with therapeutic potential in the treatment of insulin resistance and type 2 diabetes.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.cmet.2014.09.009DOI Listing

Publication Analysis

Top Keywords

break discovered
4
discovered 1974
4
1974 fgf1
4
fgf1 unrealized
4
unrealized role
4
role metabolism
4
metabolism suh
4
suh 2014
4
2014 report
4
report impressive
4

Similar Publications

Discovery of new inhibitors of nuclease MRE11.

Eur J Med Chem

January 2025

Department of Biology, Faculty of Medicine, Masaryk University, 62500, Brno, Czech Republic; NCBR, Faculty of Science, Masaryk University, 62500, Brno, Czech Republic. Electronic address:

MRE11 nuclease is a central player in signaling and processing DNA damage, and in resolving stalled replication forks. Here, we describe the identification and characterization of new MRE11 inhibitors MU147 and MU1409. Both compounds inhibit MRE11 nuclease more specifically and effectively than the relatively weak state-of-the-art inhibitor mirin.

View Article and Find Full Text PDF

Unveiling the enzymatic pathway of UMG-SP2 urethanase: insights into polyurethane degradation at the atomic level.

Chem Sci

December 2024

LAQV@REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto Rua do Campo Alegre s/n 4169-007 Porto Portugal

The recently discovered metagenomic urethanases UMG-SP1, UMG-SP2, and UMG-SP3 have emerged as promising tools to establish a bio-based recycling approach for polyurethane (PU) waste. These enzymes are capable of hydrolyzing urethane bonds in low molecular weight dicarbamates as well as in thermoplastic PU and the amide bond in polyamide employing a Ser-Ser -Lys triad for catalysis, similar to members of the amidase signature protein superfamily. Understanding the catalytic mechanism of these urethanases is crucial for enhancing their enzymatic activity and improving PU bio-recycling processes.

View Article and Find Full Text PDF

Feature selection (FS) is a key process in many pattern-recognition tasks, which reduces dimensionality by eliminating redundant or irrelevant features. However, for complex high-dimensional issues, traditional FS methods cannot find the ideal feature combination. To overcome this disadvantage, this paper presents a multispiral whale optimization algorithm (MSWOA) for feature selection.

View Article and Find Full Text PDF

Beyond Nucleotide Excision Repair: The Importance of XPF in Base Excision Repair and Its Impact on Cancer, Inflammation, and Aging.

Int J Mol Sci

December 2024

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.

DNA repair involves various intricate pathways that work together to maintain genome integrity. XPF (ERCC4) is a structural endonuclease that forms a heterodimer with ERCC1 that is critical in both single-strand break repair (SSBR) and double-strand break repair (DSBR). Although the mechanistic function of ERCC1/XPF has been established in nucleotide excision repair (NER), its role in long-patch base excision repair (BER) has recently been discovered through the 5'-Gap pathway.

View Article and Find Full Text PDF

Bovine herpesvirus 1 (BoHV-1) productive infection induces the generation of DNA double-strand breaks (DSBs), which may consequently lead to cell apoptosis. In response to DSBs, the DNA damage repair-related protein 53BP1 is recruited to the sites of DSBs, leading to the formation of 53BP1foci, which are crucial for the repair of damaged DNA and maintaining genomic integrity by repairing DSBs. In this study, we discovered that HMGA1 may play a significant role in counteracting virus infection-induced DNA damage, as the siRNA-mediated knockdown of HMGA1 protein expression or inhibition of HMGA1 activity by the chemical inhibitor Netropsin uniformly exacerbates the DNA damage induced by BoHV-1 productive infection.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!