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Anorexia nervosa is associated with higher brain mu-opioid receptor availability.
Mol Psychiatry
January 2025
Turku PET Centre, University of Turku, Turku, Finland.
Anorexia nervosa (AN) is a severe psychiatric disorder, characterized by restricted eating, fear to gain weight, and a distorted body image. Mu-opioid receptor (MOR) functions as a part of complex opioid system and supports both homeostatic and hedonic control of eating behavior. Thirteen patients with AN and thirteen healthy controls (HC) were included in this study.
View Article and Find Full Text PDFDanggui Buxue Decoction Regulates Autophagy to Improve Renal Fibrosis in diabetes through miR-27a /PI3K/AKT pathway.
J Ethnopharmacol
January 2025
School of Integrative Medicine, Nanjing University of Chinese Medicine, Jiangsu, Nanjing 210023. Electronic address:
Ethnopharmacological Relevance: Danggui Buxue Decoction (DBD) is a classic traditional Chinese herbal formulation, composed of Astragali Radix (AR) and Angelica Sinensis Radix (ASR) in a ratio of 5:1. It is a traditional Chinese medicine classic prescription for nourishing Qi and Yin (vital energy and body fluids), and it is effective in treating various clinical diseases. Diabetic nephropathy (DN) is categorized under "thirsting," "edema," and "turbid urine" in Traditional Chinese Medicine (TCM).
View Article and Find Full Text PDFProline enhances the hepatic induction of lipogenic gene expression in male hepatic fasn reporter mice.
Biochem Biophys Res Commun
January 2025
Department of Physiology and Metabolism, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan; Metabolism and Nutrition Research Unit, Institute for Frontier Science Initiative, Kanazawa University, 13-1 Takaramachi, 920-8640, Kanazawa, Ishikawa, Japan. Electronic address:
Hepatic de novo lipogenesis (DNL) is increased by both carbohydrate intake and protein consumption. In hepatic fat synthesis, a key role is played by the induction of the hepatic expression of lipogenic genes, including Fasn, Scd1, and Srebf1. Regarding carbohydrate intake, increased blood glucose and insulin levels promote the expression of hepatic lipogenic genes.
View Article and Find Full Text PDF1-phenyl-3-methyl-5-pyrazolone activates the AMPK pathway to alleviate western-diet induced metabolic dysfunction-associated steatohepatitis in mice.
Clin Nutr
January 2025
Department of Hepatology, Hepatology Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China; Fujian Clinical Research Center for Hepatopathy and Intestinal Diseases, China; Key Speciality of Infection in Fujian Province, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian, China. Electronic address:
Background & Aims: Approved drugs for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) are limited, although it has become the most common chronic liver disease worldwide. 1-phenyl-3-methyl-5-pyrazolone (PMP) possesses various biological effects such as anti-inflammatory and antioxidant. However, the effects and underlying mechanism of PMP in MASH remain unclear.
View Article and Find Full Text PDFLive-cell metabolic analyzer protocol for measuring glucose and lactate metabolic changes in human cells.
STAR Protoc
January 2025
Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan. Electronic address:
Understanding metabolic conditions related to glycolysis dependence is crucial for developing new treatments in cancer and regenerative medicine. This protocol details a method for using the live-cell metabolic analyzer (LiCellMo) to measure continuous changes in glucose consumption and lactate production in cultured human cells. LiCellMo provides real-time data on consecutive metabolic changes, improving measurements of these processes in various contexts, including in cancer and regenerative treatments.
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