AI Article Synopsis

  • In the field of cell-surface engineering, the activities of encapsulated cells can be controlled by adjusting parameters of their artificial shells, such as stiffness, thickness, and porosity.
  • Inorganic shells offer better mechanical durability and stability compared to organic ones; however, controlling their thickness has been challenging.
  • This study combines layer-by-layer techniques with bioinspired silicification to regulate silica shell thickness around individual yeast cells and examines how this thickness affects microbial growth.

Article Abstract

In the area of cell-surface engineering with nanomaterials, the metabolic and functional activities of the encapsulated cells are manipulated and controlled by various parameters of the artificial shells that encase the cells, such as stiffness and elasticity, thickness, and porosity. The mechanical durability and physicochemical stability of inorganic shells prove superior to layer-by-layer-based organic shells with regard to cytoprotection, but it has been difficult to vary the parameters of inorganic shells including their thickness. In this work, we combine the layer-by-layer technique with a process of bioinspired silicification to control the thickness of the silica shells that encapsulate yeast Saccharomyces cerevisiae cells individually, and investigate the thickness-dependent microbial growth.

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http://dx.doi.org/10.1002/asia.201402993DOI Listing

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