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Clinical phenotypes in acute and chronic infarction explained through human ventricular electromechanical modelling and simulations.
Elife
December 2024
Department of Computer Science, University of Oxford, Oxford, United Kingdom.
Sudden death after myocardial infarction (MI) is associated with electrophysiological heterogeneities and ionic current remodelling. Low ejection fraction (EF) is used in risk stratification, but its mechanistic links with pro-arrhythmic heterogeneities are unknown. We aim to provide mechanistic explanations of clinical phenotypes in acute and chronic MI, from ionic current remodelling to ECG and EF, using human electromechanical modelling and simulation to augment experimental and clinical investigations.
View Article and Find Full Text PDFBrugada phenocopy in fulminant eosinophilic myocarditis: a case series.
Eur Heart J Case Rep
December 2024
Department of Cardiology, Tsuyama Chuo Hospital, 1756 Kawasaki, Tsuyama, Okayama 708-0841, Japan.
Background: Brugada phenocopy (BrP) is a condition that induces reversible Brugada-like electrocardiographic (ECG) changes in patients without true Brugada syndrome. We present two cases of fulminant eosinophilic myocarditis that showed Type 1 Brugada ECG changes in the early phase of the clinical course.
Case Summary: Case 1 was a 76-year-old man who developed fulminant eosinophilic myocarditis with ventricular tachycardia while hospitalized for heart failure.
Brugada Phenocopy Induced by BRAF and MEK Inhibitors in a Lung Adenocarcinoma.
J Cardiovasc Electrophysiol
December 2024
Division of Cardiology, Department of Medicine, University of Verona, Verona, Italy.
Management of patients with drug-induced type 1 Brugada pattern is complex and controversial. We report the case of a 66-year-old man affected by metastatic lung adenocarcinoma with type 1 Brugada phenocopy at electrocardiogram (ECG) after initiation of an oncological therapy with BRAF and MEK inhibitors.
View Article and Find Full Text PDFType 1 Brugada ECG pattern in a patient with acute myocarditis: A case report: Is this a coincidental or a consequential association?
Heart Rhythm O2
November 2024
Cardiology Department, Abderrahmane Mami Hospital, Ariana, Tunisia.
Complex mechanism of brugada phenocopy: moderate hyponatremia and right ventricular compression by liver metastatic tumor - case report.
Wiad Lek
September 2024
DEPARTMENT OF INTERNAL MEDICINE, JÓZEF STRUŚ HOSPITAL, POZNAŃ, POLAND.
Article Synopsis
- - Brugada phenocopy (BrP) is characterized by a Brugada-like ECG pattern and can occur due to various conditions, but it doesn't increase the risk of serious heart issues like Brugada syndrome (BrS) does.
- - A case is presented of a 69-year-old woman with moderate hyponatremia who exhibited a saddle-back ST-segment elevation on her ECG, which was linked to her liver metastases compressing her heart.
- - The ECG changes resolved quickly after treating her hyponatremia with sodium chloride, demonstrating that even mild electrolyte imbalances can lead to BrP when compounded by other factors like mechanical heart compression.
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