AI Article Synopsis
- Four new yanuthone analogs (1-4) were discovered from the fungus Aspergillus niger, identified using advanced analytical techniques like UHPLC-DAD-HRMS and NMR spectroscopy.
- The compounds were categorized into three class I yanuthones (yanuthone K, L, and M) derived from 6-methylsalicylic acid, and one class II yanuthone, named yanuthone X2.
- All four compounds showed antifungal activity against Candida albicans, with yanuthone X2 being notable as the first bioactive example of a class II yanuthone, highlighting its potential for pharmaceutical applications.
Article Abstract
Four new yanuthone analogs (1-4) were isolated from the filamentous fungus Aspergillus niger. The structures of the new compounds were elucidated on the basis of UHPLC-DAD-HRMS data and one-dimensional and two-dimensional NMR spectroscopy. Labeling studies with (13)C8-6-methylsalicylic acid identified three class I yanuthones originating from the polyketide 6-methylsalicylic acid (yanuthone K, L and M (1-3)) and a class II yanuthone, which was named yanuthone X2 (4). The four new compounds were tested toward the pathogenic yeast Candida albicans and all displayed antifungal activity. Yanuthone X2 represents the first example of a bioactive class II yanuthone, demonstrating the pharmaceutical potential of this class.
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