Detailed observational data on urolithiasis incidence at the territory of the Amur Region are presented. 4 foci with a high level of disease incidence have been detected. The content of calcium, magnesium, and strontium has been determined in drinking water and correlation of urolithic disease rates with rations Ca/Sr and Mg/Sr were established. Certain dependence of the disease rates on the above ratios shows that their elevation corresponds to the reduction of urolithiasis rates, and vice versa. Application of the given technique in the urolithiasis endemic areas with the established level of disease incidence provides analogous results. It is assumed that in a number of cases unfavourable distribution of some chemical elements in drinking water, i. e., Ca/Sr and Mg/Sr, has affected the high level of urolithiasis incidence.

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