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Lung transplant pathology: No longer through a glass darkly?
J Heart Lung Transplant
October 2024
Macquarie Respiratory and Sleep Unit, Macquarie University Hospital, Sydney, NSW 2109, Australia. Electronic address:
Applications of Artificial Intelligence (AI) deep-learning models to screening for clinical conditions continue to evolve. Instances provided in this treatise include using a simple one-view PA chest radiograph to screen for Type 2 Diabetes Mellitus (T2DM), congestive heart failure, valvular heart disease, and to assess mortality in asymptomatic persons with respiratory diseases. This technology incorporates hundreds of thousands of CXRs into a convoluted neural network and is generally named AI CXR.
View Article and Find Full Text PDFSeeing through a glass darkly: Uncertainties about palliative care for patients with interstitial lung disease.
Respirology
July 2023
School of Medicine and Public Health, The University of Newcastle, Callaghan, New South Wales, Australia.
Through a Glass Darkly: a clinical journey.
Am J Psychoanal
September 2022
, 3093 West Mockingbird Lane, Tucson, AZ, 85713, USA.
The use of the empathic mode for engaging and communicating with patients has become widely accepted by many psychoanalytic psychotherapists since Kohut's early formulations (Kohut, 1971; Atwood & Stolorow, 2014). However, diagnostic understanding based on ongoing empathic immersion with our patients is often complicated because it is continually being modified as we know them more deeply and as transference and countertransference factors influence our perceptions. To illustrate the complexity of diagnosis when it is grounded in ongoing empathic engagement with our patients, I describe in detail my treatment of an elderly woman who initially presented with severe and acute symptoms of psychological, cognitive, and physical impairment.
View Article and Find Full Text PDFThrough a glass, darkly? HepaRG and HepG2 cells as models of human phase I drug metabolism.
Drug Metab Rev
February 2022
Systems Medicine, School of Medicine, University of Dundee, Jacqui Wood Cancer Centre, Ninewells Hospital, Dundee, UK.
The pharmacokinetic and safety assessment of drug candidates is becoming increasingly dependent upon models of hepatic metabolism and toxicity. Predominant among these is the HepG2 cell line, although HepaRG is becoming increasingly popular because of its perceived closer resemblance to human hepatocytes. We review the functionality of these cell lines in terms of Phase I protein expression, basal cytochrome P450-dependent activity, and utility in P450 induction studies.
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