Monoclonal antibodies (Mab) have defined functional T lymphocyte subsets in mouse and man: Ly-1/OKT4 positive helper T cells, Ly-123/OKT8 positive killer T cells and Ly-23/OKT8 positive suppressor T cells. An equivalent array of useful reagents for B-cell subsets is not yet available-although many laboratories are trying to produce them. In this review Ian Mckenzie and Heddy Zola summarize the Mob which are available and which detect polymorphic or monomorphic determinants on the B-cell surface in both man and mouse.
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