Background: Local anesthetic is one of the cornerstones of multimodal analgesia. We investigated the efficacy of the lidocaine patch for acute pain management.
Methods: We searched MEDLINE, CINAHL, Scopus, and the Cochrane Controlled Trials Register for published prospective controlled clinical trials that evaluated the analgesic effect of the lidocaine patch for acute or postoperative pain management (1966--2014). The outcomes were postoperative opioid consumption, pain intensity and length of hospital stay.
Results: Five trials comparing the lidocaine patch with control (no treatment/placebo) for acute or postoperative pain treatment/management were included in this meta-analysis. Data was analyzed on 251 patients. Between the lidocaine patch group and the control group, no significant difference was found for all three outcomes (all p > 0.05). For postoperative opioid consumption, mean difference (MD) was -8.2 mg morphine equivalent (95% CI -28.68, 12.24). For postoperative pain intensity, MD was -9.1 mm visual analog scale or equivalent (95% CI -23.31, 5.20). For length of hospital stay, MD was -0.2 days (95% CI -0.80, 0.43).
Conclusion: Application of a lidocaine patch may not be an effective adjunct for acute and postoperative pain management, in terms of pain intensity, opioid consumption and length of hospital stay.
Limitations: The limitations were a small number of included studies, potential biases from some unblinded studies, clinical heterogeneity between studies, and incomplete reported data for adjunct analgesics.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1185/03007995.2014.973484 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effectiveness of tramadol or topic lidocaine compared to epidural or opioid analgesia on postoperative analgesia in laparoscopic colorectal tumor resection.
Radiol Oncol
January 2025
1Clinical Department of Anaesthesiology and Intensive Care Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Background: Chronic postoperative pain is the most common postoperative complication that impairs quality of life. Postoperative pain gradually develops into neuropathic pain. Multimodal analgesia targets multiple points in the pain pathway and influences the mechanisms of pain chronification.
View Article and Find Full Text PDFEfficacy of Preemptive Topical Lidocaine 5% Plaster in the Prevention of Post-Craniotomy Pain, a Randomized Clinical Trial.
J Pain Res
December 2024
Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People's Republic of China.
Objective: The current landscape is characterized by a dearth of effective, safe, simple, and noninvasive methods for preventing pain following craniotomy. This clinical trial seeks to evaluate the efficacy profile of preemptive application of a topical 5% lidocaine patch in alleviating post-craniotomy pain.
Methods: This was a multi-centric, prospective randomized placebo-controlled triple-blind clinical trial.
Highly Water-Soluble Microneedle Patch for Short Wear Time and Rapid Drug Delivery.
Mol Pharm
January 2025
School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States.
Article Synopsis
- * The development of a new type of microneedle (MN) patch, made from a polymer/drug mix, allows for quick and painless application to the skin for both local and systemic drug delivery.
- * A specific MN patch design using polyvinylpyrrolidone (PVP) and lidocaine (L) with added sodium bicarbonate (NaB) enhances MN dissolution speed by 60%, enabling a much shorter wear time for effective pain relief.
Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review.
J Diabetes Metab Disord
December 2024
Anesthesiology Department, State University of Campinas, Campinas, Brazil.
Article Synopsis
- - The study reviewed the effectiveness of topical medications for diabetic neuropathic pain (DNP) and compared them with oral pain relief options.
- - The most promising topical treatments identified were 8% Capsaicin patches and 5% Lidocaine patches, along with evidence supporting topical clonidine, gabapentin, and amitriptyline.
- - Topical medications could be viable alternatives to oral medications for DNP, and further research is needed on combining different topical treatments for better effectiveness.
Effect of 5% lidocaine-medicated plaster in preventing chronic postsurgical pain after knee replacement: protocol for a randomized double-blind placebo-controlled trial.
Front Pharmacol
October 2024
Department of Pain Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.
Background: With an aging population, knee arthroplasty is increasingly common; however, chronic postsurgical pain (CPSP) affects up to 30% of patients. This study aims to evaluate the efficacy of 5% lidocaine-medicated plaster (LP5) in preventing CPSP among patients undergoing knee arthroplasty.
Methods: This is a dual-center, randomized, double-blind, placebo-controlled trial involving 128 adult patients scheduled for knee arthroplasty.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!