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Ameliorative effect of propolis against cyclophosphamide-induced toxicity in mice. | LitMetric

AI Article Synopsis

  • - Cyclophosphamide (CTX) is an effective cancer treatment but can cause harmful oxidative stress, leading to significant toxicity in patients.
  • - This study investigated the protective effects of propolis, a natural antioxidant, in mitigating CTX-induced damage in mice, with results showing improvements in various health parameters and better organ structure.
  • - The findings suggest that propolis may serve as a beneficial agent to reduce the negative side effects of CTX while enhancing overall health outcomes.

Article Abstract

Context: Cyclophosphamide (CTX) is a common anticancer agent used for the treatment of several malignancies. However, upon treatment, it induces severe toxicity due to its oxidative stress capability. Propolis, a natural product collected by honey bees, has shown several biological activities, such as free radical scavenging and antioxidant agent.

Objective: This study elucidates the protective effects of propolis against CTX-induced changes in mice.

Materials And Methods: Forty-eight male Swiss albino mice were divided into four groups; group 1 was intraperitoneally (i.p.) injected with 200 µL of phosphate buffer saline (PBS), group 2 was injected with 100 mg/kg/d propolis, group 3 was injected with a single dose of CTX (200 mg/kg), and group 4 was injected with a single dose of CTX (200 mg/kg) followed by propolis (100 mg/kg) for 7 consecutive days. After 12 d, mice were bled and then sacrificed to analyze the hematological, biochemical, and histological parameters.

Results: The results indicated that CTX-injected mice showed an increase in the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, and creatinine and a decrease in the total number of white blood cells (WBCs) and platelets. Moreover, dramatically changes in the histological architectures of the liver and kidney were observed. The mice that were injected with CTX/propolis showed an improvement in the levels of ALT, AST, urea, creatinine, WBCs, and platelets. Moreover, the histological picture of the liver and kidney was significantly improved.

Conclusions: In conclusion, propolis might be considered an effective agent in ameliorating the toxicity resulted from CTX treatment.

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Source
http://dx.doi.org/10.3109/13880209.2014.914230DOI Listing

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