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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4174175 | PMC |
| http://dx.doi.org/10.1097/GOX.0b013e31828e9f51 | DOI Listing |
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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Ahmadu Bello University, Zaria, Kaduna, Nigeria.
Background: Sleep deprivation leads to an increase in oxidative stress and activation of inflammatory response and both could increase the production and accumulation of toxic beta-amyloid in the hippocampus which is considered one of the molecular drivers of Alzheimer's pathogenesis and progression. Despite these findings, obtaining sleep is still challenging in our modern society that values work around the clock. Omega-3 fatty acids represents an active biological agent with vital antioxidant and anti-inflammatory activities that could protect memory in the face of insufficient sleep.
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Alzheimers Dement
December 2024
University of Toronto, Toronto, ON, Canada.
Background: Drug discovery efforts in neurological diseases, such as Alzheimer's disease (AD), have had particularly poor outcomes due to the lack of models that capture the cerebral vasculature. There is an unmet need to develop models that capture the physiological challenge of overcoming the blood-brain barrier (BBB) and impacts of blood flow-induced shear stress. In this work, we use a microfluidic platform to model the cerebral vasculature in familial AD (fAD) using patient-derived brain endothelial-like cells (BECs) and neurons.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Michigan State University, East Lansing, MI, USA.
Background: Abnormal phosphorylation of tau is key to Alzheimer's disease progression. The details of cellular dysfunction or death caused by hyperphosphorylated tau remain unclear. It is crucial to understand the mechanism for drug design.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Purdue University, West Lafayette, IN, USA.
Background: Exposure to environmental chemicals such as lead (Pb) during vulnerable developmental periods and even in adult stage can result in adverse health outcomes later in life. Human cohort studies have demonstrated associations between Pb exposure and Alzheimer's Disease (AD) onset in later life which were further corroborated by findings from animal studies. The molecular pathway linking Pb exposure and increased AD risk, however, remains elusive.
View Article and Find Full Text PDFBackground: Greater physical activity (PA) is associated with better cognitive and vascular health, but accurate assessment of PA is challenging. Self-report questionnaires of PA may be compared against objective measures from smartwatch sensors; the correspondence between measures may be influenced by a variety of factors such as cognition or age. The focus of this study was to identify baseline participant characteristics (vascular risk, cognition) that influence the association between self-reported PA and PA measured with a Garmin Vivosmart 4 smartwatch in a racially diverse sample of older adults.
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