Synthesis and SAR investigation of 2-guanidinoquinazolines, initially identified in a high content screen for selective STAT3 pathway inhibitors, led to a more potent analog (11c) that demonstrated improved anti-proliferative activity against a panel of HNSCC cell lines.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250329 | PMC |
| http://dx.doi.org/10.1016/j.bmcl.2014.09.001 | DOI Listing |
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