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When Pain Relief Turns Perilous: Uncovering the Hidden Dangers and Advanced Management of Benzocaine-Induced Methemoglobinemia.
Cureus
August 2024
Infectious Diseases, University of Alabama at Birmingham, Birmingham, USA.
Article Synopsis
- * A case involving a 61-year-old woman who experienced respiratory failure after surgery highlighted how benzocaine spray for throat pain may have triggered her methemoglobinemia, worsening her pneumonia symptoms.
- * The patient was successfully treated with high doses of vitamin C and methylene blue, prompting this report to stress the importance of quick diagnosis and treatment for better recovery outcomes.
Management of Congenital Methemoglobinemia in the Perioperative Setting: A Case Report and Review of Current Literature.
J Blood Med
August 2024
Department of Anesthesiology, Critical Care and Perioperative MedicineHamad Medical Corporation, Doha, Qatar.
Article Synopsis
- - Methemoglobinemia is a condition where hemoglobin is oxidized, preventing it from binding oxygen, leading to symptoms like cyanosis and potential heart failure; it can be congenital or acquired, with the congenital form being rare.
- - A case study of a 22-year-old man with congenital methemoglobinemia demonstrated the need for careful perioperative management during dental surgery, including avoiding certain anesthetics and ensuring appropriate oxygenation levels.
- - Effective management of congenital methemoglobinemia during surgery requires preoperative assessment, multidisciplinary care, avoidance of oxidizing agents, and strategies to maintain the patient's oxygenation and cardiovascular stability.
A novel stoploss mutation CYB5R3 c.906A>G(p.*302Trpext*42) involved in the pathogenesis of hereditary methemoglobinemia.
Clin Chim Acta
January 2025
Department of Traditional Chinese Medicine, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou 350001, China; Department of Hematology, Fujian Provincial Hospital, Fuzhou 350001, China. Electronic address:
Recessive congenital methemoglobinemia (RCM) is a hereditary autosomal disorder with an extremely low incidence rate. Here, we report a case of methemoglobinemia type I in a patient with congenital persistent cyanosis. The condition was attributed to a novel compound heterozygous mutation in CYB5R3, characterized by elevated methemoglobin levels (13.
View Article and Find Full Text PDFEMLA cream in burns: A systematic review of safety, analgesic efficacy, and effects on burn pathophysiology.
J Plast Reconstr Aesthet Surg
August 2024
Department of Plastic Surgery and Burn Treatment, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark.
Aim: Management of procedural pain in burn care is challenging. Lidocaine-prilocaine cream 5%, eutectic mixture of local anesthetics (EMLA®), is a widely used, effective local anesthetic cream approved for normal intact skin, genital mucosa for superficial surgical procedures, and debridement of chronic leg ulcers. This comprehensive review aimed to determine the safety, analgesic efficacy, and effects of EMLA on burn pathophysiology to provide evidence-based clinical recommendations for introducing the topical anesthetic into burn care.
View Article and Find Full Text PDFTopical glyceryl trinitrate to increase radial artery diameter in neonates: study protocol for a randomized controlled trial.
Crit Care Sci
April 2024
Neonatal Clinical Care Unit, Department of Neonatology, Perth Children's Hospital - Nedlands, Perth, Western Australia.
Background: Newborn infants admitted to the neonatal intensive care unit require arterial cannulation for hemodynamic monitoring and blood sampling. Arterial access is achieved through catheterization of umbilical or peripheral arteries. Peripheral artery cannulation is performed in critically ill newborns, but artery localization and cannulation is often challenging and unsuccessful.
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