Background/aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety.
Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups.
Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05).
Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4477993 | PMC |
| http://dx.doi.org/10.5009/gnl14010 | DOI Listing |
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Article Synopsis
- Colonoscopy is important for diagnosing and treating conditions, and effective bowel cleansing is crucial, but there's no standard preparation for children.
- A systematic review of six studies compared the effectiveness and safety of polyethylene glycol (PEG) and sodium picosulfate (SPMC) for this purpose, finding both to be effective.
- SPMC was generally preferred for its better acceptability and compliance, resulted in fewer instances of needing a nasogastric tube, and a split-dose preparation was found to be more effective than a day-before regimen.
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