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Omalizumab and IgE in the Control of Severe Allergic Asthma.
Front Pharmacol
March 2022
Department of Internal Medicine, Division of Respiratory Medicine, Nihon University School of Medicine, Tokyo, Japan.
Omalizumab, a human immunoglobulin (Ig)G1 antibody against IgE, is a therapeutic agent for bronchial asthma. The Global Initiative for Asthma guidelines indicate that the use of omalizumab should be considered as an option in step 5 of treatment for patients with the most severe type of bronchial asthma. In patients with atopic asthma who are at a high risk of exacerbation, and in whom symptoms are poorly controlled despite treatment with inhaled corticosteroids, omalizumab is one of the few drugs that improves symptoms, reduces the risk of exacerbation, and improves the quality of life while offering a high level of safety.
View Article and Find Full Text PDFDefining the Allergic Endotype of Chronic Rhinosinusitis by Structured Histopathology and Clinical Variables.
J Allergy Clin Immunol Pract
October 2021
Section of Allergy/Immunology, Department of Internal Medicine, Rush University Medical Center, Chicago, Ill. Electronic address:
Background: Atopy has a strong association with chronic rhinosinusitis (CRS).
Objective: To understand whether patients with atopy and CRS can be defined by markers of tissue histopathology, systemic biomarkers, and clinical factors, which may guide their response to new pharmacologic agents.
Methods: In a retrospective cohort of CRS patients who underwent functional endoscopic sinus surgery, a structured histopathology report consisting of 12 variables, comorbid conditions, preoperative total serum IgE levels, and preoperative modified Lund-Kennedy endoscopic and sinonasal outcome test (SNOT-22) scores were compared between atopic CRS (aCRS) and non-aCRS control patients in a multivariable model.
Effects of Omalizumab on FcεRI and IgE Expression in Lesional Skin of Bullous Pemphigoid.
Front Immunol
October 2020
Department of Dermatology, Inselspital-Bern University Hospital, University of Bern, Bern, Switzerland.
Recent studies suggest an important role of immunoglobulin E (IgE) as an alternative pathogenic pathway in the development of bullous pemphigoid (BP), as the most frequent subepidermal blistering disease of the skin Use of IgE targeted therapies, such as omalizumab, has been shown promising in recent studies. The aim of this study was to assess the effect of omalizumab on FcεRI and IgE expression on circulating basophils and on lesional intradermal cells in BP to generate insight into the immunological effects of omalizumab in BP. We report two cases of BP patients treated with omalizumab.
View Article and Find Full Text PDFAllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing mice.
World Allergy Organ J
July 2019
Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Austria.
Background: Atopics have a lower risk for malignancies, and IgE targeted to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or adaptive immune surveillance can confer protection against tumors remains unclear.
Objective: We aimed to investigate the effects of active and passive immunotherapy to the tumor-associated antigen HER-2 in three murine models differing in Epsilon-B-cell-receptor expression affecting the levels of expressed IgE.
In vivo assay of IgE activities on the expulsion of intestinal adult worms.
Parasitol Int
October 2016
Department of Immunology, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. Electronic address:
A physiological role of immunoglobulin E (IgE) is to promote parasitic helminth expulsion. This assertion is largely based on a series of studies carried out by Capron's laboratory. They observed that IgE is an essential component of protective immunity against Schistosoma mansoni larvae both in vitro and in vivo.
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