AI Article Synopsis
- The study aimed to examine the levels of DAB2IP protein in bladder transitional cell carcinoma (BTCC) and its relation to clinical features and patient prognosis.
- It used immunohistochemical staining on tissue samples from 79 BTCC cases and 11 normal bladder cases, analyzing the connection between DAB2IP levels and factors like cancer stage, grade, and survival rates.
- Results showed that lower DAB2IP expression in BTCC tissue correlated with higher grade and metastasis, and patients with higher DAB2IP levels had better 3-year survival rates, suggesting DAB2IP is crucial in inhibiting BTCC progression.
Article Abstract
Objective: To investigate the expression of DAB2IP in bladder transitional cell carcinoma (BTCC) and its correlation with clinical characteristics and prognosis of BTCC patients.
Methods: Immunohistochemical staining was applied to detect DAB2IP protein level in 79 cases of TCCB tissues and 11 cases of normal bladder tissues, and the relationships of the staining results with pathological grade, stage, lymph node metastasis, gender, age and the 3-year survival rate of the patients were analyzed.
Results: The expression of DAB2IP in BTCC tissues was significantly lower than that in normal bladder epithelium, and the expression score and rate of DAB2IP in the high-grade, invasive and metastatic BTCC were significantly lower than those in low-grade, superficial and non-metastatic BTCC (P < 0.05). The 3-year survival rate of the patients with high DAB2IP expression was significantly higher than that of the patients with low DAB2IP expression.
Conclusion: DAB2IP may be one of the important inhibitory factors during the occurrence and progression of BTCC.
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