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Hemoglobin-based oxygen carriers: Biochemical, biophysical differences, and safety.
Transfusion
January 2025
Office of Blood Research and Review, Center for Biologics Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland, USA.
Development of hemoglobin microbubbles for acoustic blood oxygen sensing: A study on PEGylation and gas core modification for in vivo applications.
Acta Biomater
December 2024
Department of Bioengineering, Erik Johnson School of Engineering, The University of Texas at Dallas. Electronic address:
The creation of innovative ultrasound contrast agents (UCAs) with the ability to monitor oxygen levels in real-time holds immense potential for advancing early diagnosis of various medical conditions such as hypoxic/reperfusion injury. In this study, we propose the development of oxygen sensitive UCAs using microbubbles composed of hemoglobin (HbMBs), which can function as sensors for blood oxygen levels. Previously, we performed a study highlighting the initial proof-of-concept efficacy of air-filled HbMBs in detecting oxygenation changes in vitro, offering a promising tool for clinically detecting tissue hypoxia.
View Article and Find Full Text PDFArtificial blood-hope and the challenges to combat tumor hypoxia for anti-cancer therapy.
Med Biol Eng Comput
November 2024
Amity Stem Cell Institute, Amity Medical School, Amity University Haryana, Amity Education Valley, Panchgaon, Manesar (Gurugram), Haryana, 122413, India.
Article Synopsis
- - Blood is essential for the body, transporting hormones, regulating temperature and pH, and playing a key role in immune defense and healing through white blood cells and platelets.
- - The circulatory system, made up of arteries, veins, and capillaries, ensures the efficient delivery of nutrients and oxygen but often faces challenges like shortages and compatibility issues, making artificial blood alternatives important.
- - Our study focused on using artificial blood, including red blood cell substitutes and artificial platelets, to improve cancer therapy by addressing issues like tumor hypoxia and enhancing treatment outcomes.
In vitro and in vivo investigations of hemoglobin-loaded PEGylated ZIF-8 nanoparticles as oxygen carriers for emergency transfusion.
Biomater Adv
March 2025
Department of Health Technology, Technical University of Denmark, Kgs. Lyngby 2800, Denmark. Electronic address:
The limitations of traditional blood supply systems, particularly where ideal storage is unfeasible, challenge the efficacy of transfusion medicine, especially in emergencies and battlefield scenarios. This study investigates a novel hemoglobin-based oxygen carrier (HBOC) using a dual-coating approach with metal phenolic networks (MPNs) and polyethylene glycol (PEG). Utilizing zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for their porosity and biocompatibility, the addition of MPN and PEG coatings enhances biocompatibility and stabilizes encapsulated hemoglobin (Hb).
View Article and Find Full Text PDFScalable Production and Biophysical Characterization of High-Molecular-Weight Relaxed and Tense Quaternary State Polymerized Human Hemoglobin as Potential Red Blood Cell Substitutes.
Biomacromolecules
November 2024
William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, United States.
High-molecular-weight (HMW) (>500 kDa) glutaraldehyde-polymerized human hemoglobin (PolyhHb) is a promising hemoglobin-based oxygen carrier (HBOC) due to its decreased risk of vasoconstriction and oxidative tissue injury. Previously, HMW tense (T) quaternary state PolyhHb was synthesized at the pilot scale with tangential flow filtration (TFF) for the removal of low-molecular-weight species. However, T-state PolyhHb is limited to specific biomedical applications due to its low oxygen affinity, thus motivating the need to produce high oxygen affinity relaxed (R) quaternary state PolyhHb at the pilot scale.
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