An evaluation of SERI surgical scaffold for soft-tissue support and repair in an ovine model of two-stage breast reconstruction.

Plast Reconstr Surg

Los Angeles, Calif; Medford and North Grafton, Mass.; and Logan and Salt Lake City, Utah From the Keck School of Medicine, University of Southern California; Allergan, Inc.; Innovative Medical Device Solutions; the University of Utah School of Medicine; ARUP Laboratories; and the Cummings School of Veterinary Medicine, Tufts University.

Published: November 2014

This study was designed to evaluate the SERI Surgical Scaffold, a silk-derived bioresorbable scaffold, in an ovine model of two-stage breast reconstruction. Sheep were implanted bilaterally with either SERI or sham sutures during the stage 1 procedure. The SERI group underwent an exchange procedure for a breast implant at 3 months; animals in the sham group were killed at 3 months. The sham samples were significantly weaker than the SERI plus tissue samples by 3 months. At all endpoints, SERI plus tissue samples were greater than or equal to 150 percent of native ovine fascial strength. Histologic evaluation of SERI samples showed evidence of bioresorption through 12 months. SERI provided adequate soft-tissue support with progressive bioresorption. By 12 months, newly formed tissue had assumed the majority of load-bearing responsibility.

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http://dx.doi.org/10.1097/PRS.0000000000000697DOI Listing

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