AI Article Synopsis
- The study aimed to find out if COPD and reduced lung function can predict mortality rates in different cohorts from Montevideo, Santiago, and Sao Paulo over 5-9 years.
- Key findings indicated that COPD significantly increased the risk of overall mortality and specifically cardiovascular death, particularly in patients with more severe stages (GOLD 2-4) of the disease.
- The results suggest that low FEV1 is a critical indicator for both overall and respiratory mortality, while FVC showed no significant association with overall mortality levels.
Article Abstract
Objective: To determine whether the presence of chronic obstructive lung disease (COPD) and reduction of lung function parameters were predictors of mortality in a cohort.
Materials/patients And Methods: Population based cohorts were followed in Montevideo, Santiago and Sao Paulo during 5, 6 and 9 years, respectively. Outcomes included all-cause, cardiovascular, respiratory and cancer mortality; exposures were COPD, forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Cox regression was used for analyses. Sensitivity, specificity, positive and negative predictive values, receiver operator characteristics curves and Youden's index were calculated.
Results: Main causes of death were cardiovascular, respiratory and cancer. Baseline COPD was associated with overall mortality (HR = 1.43 for FEV1/FVC
Answer To The Question: COPD and low FEV1 are important predictors for overall and cardiovascular mortality in Latin America.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186841 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0109732 | PLOS |
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