AI Article Synopsis
- Urinary bladder cancer is prevalent worldwide, and genetic variations in metabolizing enzymes may affect cancer risk.
- The study assessed 65 men with bladder cancer and 70 healthy controls from Central Anatolia, using the RFLP method to detect GSTT1 and GSTM1 polymorphisms.
- Results indicated no link between GSTM1 and bladder cancer, but those with the GSTT1 null genotype had a significantly higher risk of developing the disease compared to those with the normal genotype.
- The researchers plan to expand their study with a larger group of bladder cancer patients in the Turkish population.
Article Abstract
Background: Urinary bladder cancer is a quite common cancer type in men and women all over the world. Genetic polymorphisms of xenobiotic-metabolizing enzymes could increase individual susceptibility to various cancer types.
Aims: The aim of our study is to evaluate the rate of these polymorphisms in a group of patients from Central Anatolia.
Methods: Our study subjects consist of 65 men with histopathologically confirmed bladder TCC and 70 cancer-free control subjects. Restriction fragment length polymorphism (RFLP) method was used for the detection of polymorphisms of GSTT1 and GSTM1.
Results: There was no association between bladder cancer and GSTM1 polymorphism (ORs = 0.64, 95% CI = 0.32-1.29), but the probability of bladder cancer in patients with GSTT1 null genotype (67.9%), was significantly higher from the probability of bladder cancer with GSTT1 normal genotype (43.0%) statistically (ORs = 2.8, 95% CI = 1.16-6.75).
Conclusion: Polymorphisms of these genes have been assessed to evaluate the relative risk of various cancers. Our intention is to continue this study with larger series of bladder cancer patients in a group of Turkish population from Central Anatolia.
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| http://dx.doi.org/10.1007/s11845-014-1200-6 | DOI Listing |
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