AI Article Synopsis
- The study evaluated the effects of switching to one dose of aflibercept in patients who did not respond to bevacizumab after multiple monthly treatments.
- Visual acuity improved significantly after the switch, with 47% of patients seeing at least a 5-letter gain on a vision chart, and central retinal thickness also decreased.
- The findings suggest that administering aflibercept can enhance both visual and anatomic outcomes in patients previously unresponsive to bevacizumab.
Article Abstract
Objective: This study aimed to report on the efficacy of 1 dose of aflibercept in bevacizumab nonresponders.
Design: This was a retrospective, single-centre, interventional, noncomparative study.
Participants: This study retrospectively analyzed 23 patients with persistent intraretinal or subretinal fluid treated with 6 or more monthly bevacizumab injections.
Methods: Patients were switched to 1 dose of aflibercept and afterward continued their therapy with bevacizumab for at least another 6 months. We performed spectral domain optical coherence tomography monthly and evaluated visual acuity, central retinal thickness, and photoreceptor defects. The main outcome measures were visual and anatomic outcome 1 and 6 months after administering aflibercept.
Results: Visual acuity significantly improved (p = 0.01) after the switch to aflibercept (from 0.39 to 0.49 Snellen). This improvement was stable for the remaining 6 months of the study (final visual acuity, 0.46 Snellen); 47% of patients experienced an improvement of at least 5 letters from baseline on a chart of the ETDRS type (Early Treatment Diabetic Retinopathy Study). Central retinal thickness decreased from 521 µm to 446 µm (p = 0.01) and remained stable for the next 6 months (452 µm). Complete resolution of intraretinal and subretinal fluid was observed in 30% of eyes.
Conclusions: In bevacizumab nonresponders, switching to a single dose of aflibercept before continuing the therapy with bevacizumab improves visual outcome and anatomic results.
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| http://dx.doi.org/10.1016/j.jcjo.2014.07.012 | DOI Listing |
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