A new species of pterosaur, Maaradactylus kellneri gen. nov., sp. nov. (Archosauria: Pterosauria) from the Romualdo Formation (Aptian/Albian), is herein described. The specimen (MPSC R 2357) was found at Sítio São Gonçalo, Santana do Cariri city (State of Ceará, northeast Brazil) and consists of the skull, atlas and axis, and represents one of the largest skulls of the Anhangueridae from the Araripe Basin described. The autapomorphies of the new pterosaur include the following characters: a premaxillary sagittal crest that is relatively long and high, beginning at the anterior part of the skull (rostrum) and extending to the 22nd pair of alveoli, not covering the nasoantorbital fenestra or the choanaes, and also the presence of 35 pairs of alveoli; smooth palatal ridge, which starts on the 5th pair of alveoli and ends on the 13th pair; palate is convex shaped in the anterior region; choanae not extending laterally; small and convex palatal elevation; the 5th, 6th and 7th alveoli smaller than the 4th and 8th; the alveoli decreasing in size from the 9th to the 12th and increasing from the 13th to 18th, and from the 18th to the 35th they are arranged in triplets. Furthermore, the lateral surface of the premaxillary crest shows grooves and tridimensional structures that may have housed blood vessels.
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http://dx.doi.org/10.11646/zootaxa.3869.3.1 | DOI Listing |
Environ Geochem Health
November 2024
Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava No.6, Zona Universitaria, C.P. 78210, San Luis Potosí, México.
Constructed wetlands are used to remove diclofenac and naproxen from wastewater. However, the role of plants and their root-associated bacteria in removing these pharmaceuticals is still unknown. In this work, bacteria were isolated from the roots of Typha latifolia cultivated in a constructed wetland to treat a diclofenac and naproxen mix.
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August 2024
São Paulo State University (UNESP), Medical School, Botucatu, Experimental Research Unit (UNIPEX), Brazil. Electronic address:
The hepatocellular carcinoma (HCC) features a remarkable epidemiological burden, ranking as the third most lethal cancer worldwide. As the HCC-related molecular and cellular complexity unfolds as the disease progresses, the use of a myriad of in vitro models available is mandatory in translational preclinical research setups. In this review paper, we will compile cutting-edge information on the in vitro bioassays for HCC research, (A) emphasizing their morphological and molecular parallels with human HCC; (B) delineating the advantages and limitations of their application; and (C) offering perspectives on their prospective applications.
View Article and Find Full Text PDFJ Biochem Mol Toxicol
February 2024
Department of Pharmaceutical Sciences, University of Milan, Milan, Italy.
The nonalcoholic fatty liver disease (NAFLD), which is closely related to westernized dietary (WD) patterns, displays a rising epidemiological and economic burden. Since there is no pharmacological therapy approved for this disease, mechanistic studies are warranted. In this work, we investigated the action of carnosine (CAR), a natural dipeptide with several protection roles against oxidative stress in the liver of NAFLD rats.
View Article and Find Full Text PDFEnviron Toxicol Pharmacol
November 2023
São Paulo State University (UNESP), Botucatu Medical School, Experimental Research Unit (UNIPEX), Multimodel Drug Screening Platform - Laboratory of Chemically induced and Experimental Carcinogenesis (MDSP-LCQE), Botucatu, SP, Brazil; São Paulo State University (UNESP), Biosciences Institute, Department of Structural and Functional Biology, Botucatu, SP, Brazil. Electronic address:
We evaluated whether glyphosate promotes western diet (WD)-induced non-alcoholic fatty liver disease (NAFLD). Male C57BL/6J mice were fed WD and received intragastrical glyphosate (0.05, 5 or 50 mg/kg) for 6 months.
View Article and Find Full Text PDFInt J Exp Pathol
December 2023
Botucatu Medical School, Experimental Research Unit (UNIPEX), Multimodel Drug Screening Platform - Laboratory of Chemically Induced and Experimental Carcinogenesis (MDSP-LCQE), São Paulo State University (UNESP), Botucatu, São Paulo State, Brazil.
Colorectal cancer, which is the third leading cause of cancer-related deaths worldwide, is a multistep disease, featuring preneoplastic aberrant crypt foci (ACF) as the early morphological manifestation. The roles of hemichannel-forming transmembrane Pannexin 1 (Panx1) protein have not been investigated in the context of colon carcinogenesis yet, although it has contrasting roles in other cancer types. Thus, this study was conducted to examine the effects of Panx1 knockout (Panx1 ) on the early events of chemically induced colon carcinogenesis in mouse.
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