Introduction: Thyroid paraganglioma is a very rare malignant neuroendocrine tumor. Immunohistochemical features of thyroid paraganglioma are helpful for the diagnosis.
Case Report: A 69-year-old female came to hospital with the presence of a growing thyroid nodule of the left lobe. Ultrasonic neck examination showed 5 cm hypoechoic nodule in the left thyroid lobe. Thyroid scintigraphy showed a big cold nodule in the left lobe. Computed tomography (CT) scan showed left lobe thyroid tumor with tracheal deviation on the right site. Extended total thyroidectomy was done. Intraoperative consultation with the pathologist confirmed thyroid cancer. The pathologist diagnosed thyroid paraganglioma on the base of immuohistochemical investigation. This thyroid paraganglioma was positive for neuron-specific enolase, chomogranin A, synaptophysin, and S-100 protein highlighted the sustentacular cells. Tumor cells were negative for thyroglobulin, epithelial membrane antigen, cytokeratin, calcitonin, and carcinoembryonic. After the surgery the patient was treated with chemotherapy, peptide receptor radionuclide therapy, and permanent TSH suppressive therapy. The patient was followed with measurements of thyroid hormone and serum neuron-specific enolase, chromogranin A level, every 6 months. Gastroscopy, colonoscopy, chest and abdomen CT scan as well as further tests (chest xray, ultrasound of the neck, and whole body octreotide scintigraphy) were done. No primary neuroendocrine tumor in digestive sistem or in the chest was found. After more than 3 years the patient has no evidence of the recurrent disease.
Conclusion: Radical resection of thyroid paraganglioma, followed by chemotherapy and peptide receptor radionuclide therapy, should be considered the treatment of choice in patients with thyroid gland paraganglioma.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Risk of Biopsy and Surgical Treatment of Subglottic Paragangliomas: A Case Report.
Clin Case Rep
January 2025
Ear, Nose and Throat Centre, Xinjiang Uygur Autonomous Region People's Hospital Urumqi Xinjiang Uygur Autonomous Region China.
This report describes a rare case of a paraganglioma occurring beneath the vocal folds. During the preoperative biopsy, we encountered significant hemorrhage, forcing us to stop the procedure and preventing us from obtaining a definitive diagnosis. Despite these challenges, the eventual surgery had a good outcome.
View Article and Find Full Text PDFGenetics of urinary bladder paragangliomas: a multi-center study of a Chinese cohort.
J Endocrinol Invest
December 2024
Department of Urology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
Article Synopsis
- The study explores the genetic characteristics of urinary bladder paragangliomas (UBPGLs) in a cohort of 70 Chinese patients, aiming to better understand their heritability and genetic variations.
- Results show that 38 patients had pathogenic variants (PVs), mainly in cluster 1A genes like SDHB and HRAS, with UBPGLs showing higher PV rates in cluster 1A compared to non-head and neck PGLs.
- The findings indicate a diverse genetic profile among Chinese patients with UBPGLs, emphasizing the necessity for genetic testing to identify significant pathogenic variants.
[Value of 24-hour urinary aldosterone in diagnosis and classification of primary hyperaldosteronism].
Zhonghua Yi Xue Za Zhi
December 2024
Department of Endocrinology, Third Xiangya Hospital, Central South University, Changsha410013, China.
Article Synopsis
- The study aimed to evaluate the effectiveness of 24-hour urinary aldosterone (UEA) for diagnosing and classifying primary aldosteronism (PA) among 282 hypertensive patients admitted to a university hospital between December 2020 and December 2023.
- After excluding patients with secondary hypertension, 243 subjects were analyzed, revealing a distinction between PA (135 patients) and primary hypertension (108 patients) based on the causes of their hypertension.
- Findings showed that specific measurements like serum potassium and plasma renin activity were significantly lower in the PA group compared to the primary hypertension group, indicating potential biomarkers for PA diagnosis and classification.
Pheochromocytoma and paraganglioma are often associated with hereditary syndromes, particularly those involving genes such as , which is linked to multiple endocrine neoplasia type 2A. Genetic testing plays a crucial role in diagnosing these conditions, guiding treatment strategies, and providing early intervention options for the affected families. A 57-year-old man presenting with back pain was found to have a left adrenal tumor and a retroperitoneal tumor near the left renal hilum.
View Article and Find Full Text PDFSurgical Treatment and Clinical Evaluation of Calvarial Metastases.
J Craniofac Surg
January 2025
Department of Radiology, Tangdu Hospital, Air Force Medical University, Xi'an, Shanxi, China.
Article Synopsis
- The study investigates surgical techniques and clinical characteristics related to calvarial metastases, aiming to provide an in-depth review of treatment methods for these tumors.
- It analyzed data from 12 patients who had surgical interventions for calvarial metastatic tumors, including resection and titanium mesh repair, with all patients receiving follow-up treatments like radiotherapy and chemotherapy.
- Results indicated varied outcomes, including cases of multiple tumors requiring different treatment approaches, instances of dura mater and brain tissue invasion, and a follow-up period where some patients experienced recurrences.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!