Cerebral ischemia due to meningovascular syphilis is rare and more frequently affects the anterior circulation than the posterior circulation. We describe clinical features and imaging studies of a 50-year-old patient with Parinaud syndrome and a syphilitic dorsal midbrain infarction. Brain magnetic resonance imaging indicated vasculitis of the posterior circulation. The diagnosis of meningovascular syphilis was established by serum and cerebrospinal fluid examinations. Although rare, because of the high impact on treatment, clinicians should always be aware of meningovascular syphilis in the differential diagnosis of stroke, particularly in young and male patients with cryptogenic stroke.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2014.07.046 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Syphilitic bi-valvular endocarditis and myocarditis: modern tools applied to long-forgotten complications of a re-emerging disease.
Lancet Infect Dis
January 2025
Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada.
The incidence of syphilis has increased steadily over the past 25 years. Undiagnosed cases have presumably increased in the same proportions, and rare complications are at particularly high risk of being unrecognised. A previously healthy 60-year-old man presented with rapidly progressive heart failure and severe aortic and mitral valve insufficiency, with direct valvular destruction and preservation of the aortic valve annulus and aortic root.
View Article and Find Full Text PDFTeaching NeuroImage: Vessel Wall MRI Features of Meningovascular Syphilis.
Neurology
January 2025
From the Department of Clinical Neurosciences, University of Calgary, Cumming School of Medicine, Canada.
Analysis of Neurosyphilis Imaging Methods and Treatment: A Focused Review.
Cureus
November 2024
Medical Education, Geisinger Commonwealth School of Medicine, Scranton, USA.
Article Synopsis
- * Diagnosis relies on cerebrospinal fluid analysis and neuroimaging techniques like MRI and SPECT, and there are recent advances in testing methods and imaging to monitor treatment effectiveness.
- * The main treatment is Penicillin G, while ceftriaxone is an alternative for those allergic to penicillin; both aim to improve patient outcomes by enhancing understanding of neurosyphilis pathophysiology and refining diagnostic and treatment methods.
[Diagnostic, Therapeutic and Monitoring Approach in Suspected Neurosyphilis: Proposal for a Clinical Guideline].
Acta Med Port
December 2024
Serviço de Doenças Infeciosas. Unidade Local de Saúde de São João. Porto; Departamento de Medicina. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.
This clinical guideline was designed to serve as a hospital guide in the diagnostic, therapeutic, and monitoring approach to neurosyphilis, considering whether there is positivity or not for the human immunodeficiency virus. Syphilis is a sexually transmitted notifiable disease, known as the great imitator. In around 30% of cases of untreated disease, there is a persistent central nervous system infection.
View Article and Find Full Text PDFClinical and laboratory characteristics of asymptomatic and symptomatic neurosyphilis in HIV-infected patients: A retrospective study in China.
Medicine (Baltimore)
September 2024
Department of Neurology, Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Article Synopsis
- High rates of HIV and Treponema pallidum coinfection exist, and HIV can worsen the incidence of neurosyphilis, but risk factors for symptomatic neurosyphilis (SNS) are not well understood.
- A study reviewed the medical records of 60 male inpatients with syphilis and HIV, finding that 75% were diagnosed with SNS, with meningo-vascular neurosyphilis being most common.
- Significant factors linked to SNS include the absence of early syphilis treatment and a higher cerebrospinal fluid (CSF) white blood cell count, suggesting that closer monitoring and treatment are crucial, especially regarding young patients with unexplained strokes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!