AI Article Synopsis
- Blood uric acid (PUA) levels are linked to cardiovascular diseases (CVDs), and this study explores how arsenic exposure affects PUA levels, particularly in Bangladesh.
- Researchers collected data from 483 participants in arsenic-endemic and non-endemic areas, measuring arsenic concentrations in drinking water and bodily samples, alongside PUA levels.
- Results indicated significantly higher PUA levels in those exposed to arsenic, which correlated positively with both systolic/diastolic blood pressure and hypertension, suggesting that arsenic could play a role in increasing the risk of CVDs through elevated PUA levels.
Article Abstract
Blood uric acid has been recognized as a putative marker for cardiovascular diseases (CVDs). CVDs are the major causes of arsenic-related morbidity and mortality. However, the association of arsenic exposure with plasma uric acid (PUA) levels in relation to CVDs has not yet been explored. This study for the first time demonstrated the associations of arsenic exposure with PUA levels and its relationship with hypertension. A total of 483 subjects, 322 from arsenic-endemic and 161 from non-endemic areas in Bangladesh were recruited as study subjects. Arsenic concentrations in the drinking water, hair and nails of the study subjects were measured by inductively coupled plasma mass spectroscopy. PUA levels were measured using a colorimetric method. We found that PUA levels were significantly (p<0.001) higher in males and females living in arsenic-endemic areas than those in non-endemic area. Arsenic exposure (water, hair and nail arsenic) levels showed significant positive correlations with PUA levels. In multiple regression analyses, arsenic exposure levels were found to be the most significant contributors on PUA levels among the other variables that included age, body mass index, blood urea nitrogen, and smoking. There were dose-response relationships between arsenic exposure and PUA levels. Furthermore, diastolic and systolic blood pressure showed significant positive correlations with PUA levels. Finally, the average PUA levels were significantly higher in the hypertensive group than those in the normotensive group in both males and females living in arsenic-endemic areas. These results suggest that arsenic exposure-related elevation of PUA levels may be implicated in arsenic-induced CVDs.
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| http://dx.doi.org/10.1016/j.taap.2014.09.011 | DOI Listing |
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