Objectives: To determine the extent of inter-individual variation in clearance of midazolam in children and establish which factors are responsible for this variation.
Methods: A systematic literature review was performed to identify papers describing the clearance of midazolam in children. The following databases were searched: Medline, Embase, International Pharmaceutical Abstracts, CINAHL and Cochrane Library. From the papers, the range in plasma clearance and the coefficient of variation (CV) in plasma clearance were determined.
Results: 25 articles were identified. Only 13 studies gave the full range of clearance values for individual patients. The CV was greater in critically ill patients (18%-170%) than non-critically ill patients (13%-54%). Inter-individual variation was a major problem in all age groups of critically ill patients. The CV was 72%-106% in preterm neonates, 18%-73% in term neonates, 31%-130% in infants, 21%-170% in children and 47%-150% in adolescents. The mean clearance was higher in children (1.1-16.7 mL/min/kg) than in neonates (0.78-2.5 mL/min/kg).
Conclusions: Large inter-individual variation was seen in midazolam clearance values in critically ill neonates, infants, children and adolescents.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283666 | PMC |
| http://dx.doi.org/10.1136/archdischild-2013-305720 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Can Global DNA Methylation Be Influenced by Polymorphisms in Genes Involved in Epigenetic Mechanisms? A Review.
Genes (Basel)
November 2024
Department of Celular Biology, Federal University of Paraná-UFPR, Curitiba 80060-000, PR, Brazil.
Background: Global methylation refers to the total methylation in the DNA and can also be inferred from the Line 1 and Alu regions, as these repeats are very abundant in the genome. The main function of DNA methylation is to control gene expression and is associated with both normal and pathological mechanisms. DNA methylation depends on enzymes that generate the methyl radical (e.
View Article and Find Full Text PDFA Ge.F.I. Collaborative Study: Evaluating Reproducibility and Accuracy of a DNA-Methylation-Based Age-Predictive Assay for Routine Implementation in Forensic Casework.
Electrophoresis
January 2025
Forensic Sciences Laboratory, Section of Legal Medicine, Department of Medicine and Surgery, Santa Maria Hospital, University of Perugia, Terni, Italy.
The increasing interest in DNA methylation (DNAm) analysis within the forensic scientific community prompted a collaborative project by Ge.F.I.
View Article and Find Full Text PDFPrevious studies indicate differences in experiences of loneliness during the COVID-19 pandemic but are constricted by limited timeframes and absence of key risk factors. This study explores temporal and inter-individual variations of loneliness in Canadians over the pandemic's first year (April 2020-2021), by identifying loneliness trajectories. It then seeks to provide information about groups overrepresented in high and persistent loneliness trajectories by examining their associations with risk factors: social isolation indicators (living alone, adherence to health measures limiting in-person contacts, and online contacts), young adultood, and the interactions between these factors.
View Article and Find Full Text PDFIndividual sex-based variability to altitude training in elite badminton players.
J Sports Sci
January 2025
Laboratory Sport, Expertise and Performance (EA 7370), French Institute of Sport, Paris, France.
To assess how altitude training impacts force-velocity-power (F-V-P) profiling and muscular power and anaerobic capacity in elite badminton players in reference to intra- and inter-individual sex-based variability. Following a quasi-experimental design, 14 players (6 females, 8 males) from the French national badminton singles and doubles teams performed a 3-week 'living high-training high' camp at natural altitude (2320 m). F-V-P profile and Wingate anaerobic test were assessed Pre- and Post-intervention, using ANOVA repeated measures conventional statistics, with further estimation statistics to show the magnitude of the testing condition and visualize intra- and inter-individual responses.
View Article and Find Full Text PDFHidden Causes of Variation in Offspring Reproductive Value: Negative Effects of Maternal Breeding Age on Offspring Telomere Length Persist Undiminished Across Multiple Generations.
Ecol Lett
January 2025
School of Biodiversity, One Health and Veterinary Medicine, University of Glasgow, Glasgow, UK.
Offspring of older breeders frequently show reduced longevity, which has been linked to shorter offspring telomere length. It is currently unknown whether such telomere reduction persists beyond a single generation, as would be the case if germline transmission is involved. In a within-grandmother, multi-generational study using zebra finches, we show that the shorter telomeres observed in F1 offspring of older mothers are still present in the F2 generation even when the breeding age of their F1 mothers is young.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!