Patents directed to naturally occurring genetic material, such as DNA, RNA, chromosomes, and genes, in an isolated or purified form have been granted in Australia for many years. This review provides scientists with a summary of the gene patent debate from an Australian perspective and specifically reviews how the various levels of the legal system as they apply to patents-the Australian Patent Office, Australian courts, and Australian government-have dealt with the issue of whether genetic material is proper subject matter for a patent.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292076 | PMC |
http://dx.doi.org/10.1101/cshperspect.a020909 | DOI Listing |
Annu Rev Plant Biol
March 2025
3School of Agriculture and Environment, Faculty of Science, The University of Western Australia, Perth, Western Australia, Australia.
Phytomelatonin has attracted significant attention over the years for its roles in promoting plant growth and enhancing stress resistance. The biosynthetic pathway of phytomelatonin is more intricate than that of melatonin in animals, occurring in plants in the endoplasmic reticulum, chloroplasts, mitochondria, and cytoplasm. By compartmentalizing phytomelatonin production within specific organelles and differentially expressing biosynthesis genes, plants may finely tune the levels of this hormone under normal growth conditions, as well as in rapid responses to changing environmental conditions.
View Article and Find Full Text PDFPlant Cell
March 2025
The Institute of Plant Sciences, Agricultural Research Organization, Volcani Center, Bet Dagan, Israel.
PHYTOCHROME-INTERACTING FACTORs (PIFs) regulate growth-related gene expression in response to environmental conditions. Among their diverse functions in regulating signal responses, PIFs play an important role in thermomorphogenesis (the response to increased ambient temperature) and in the shade-avoidance response. While numerous studies have examined the varied roles of PIFs in Arabidopsis (Arabidopsis thaliana), their roles in crop plants remain poorly investigated.
View Article and Find Full Text PDFPlant Cell
March 2025
State Key Laboratory of Agricultural and Forestry Biosecurity, Ministry of Agriculture Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China.
In Arabidopsis (Arabidopsis thaliana), MICRORCHIDIA 1 (MORC1), a member of the MORC family of evolutionarily conserved GHKL-type ATPases, plays important roles in multiple layers of plant immunity. However, the molecular mechanism by which MORC1 regulates plant immunity remains obscure. Here, we report that the pathogen-responsive kinase CALCIUM-DEPENDENT PROTEIN KINASE 5 (CPK5) directly interacts with and phosphorylates MORC1, thereby promoting its stability and nuclear translocation.
View Article and Find Full Text PDFSyst Biol Reprod Med
December 2025
Department of Molecular Endocrinology, ICMR- National Institute for Research in Reproductive and Child Health, Parel, Mumbai, India.
Polycystic ovary syndrome (PCOS) is a complex polygenic endocrinopathy affecting 5-20% of reproductive-age women. Familial studies, candidate gene studies, and GWAS have identified multiple PCOS-associated genetic loci. This study aims to identify the functional variants associated with PCOS.
View Article and Find Full Text PDFSci Immunol
March 2025
Department of Biological Chemistry and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Antigen receptor signaling pathways that control lymphocyte activation depend on signaling hubs and negative regulatory proteins to fine-tune signaling outputs to ensure host defense and avoid pathogenic responses. Caspase recruitment domain-containing protein 11 (CARD11) is a critical signaling scaffold that translates T cell receptor (TCR) triggering into the activation of nuclear factor κB (NF-κB), c-Jun N-terminal kinase (JNK), mechanistic target of rapamycin (mTOR), and Akt. Here, we identify glutamine-rich protein 1 (QRICH1) as a regulator of CARD11 signaling that mediates an intracellular checkpoint for CD8 T cell activation.
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