A greener water mediated protocol for the efficient synthesis of a library of 2-amino-6-styryl pyrimidines (4) and their dihydro analogues (3) has been reported. Most of the saturated compounds (3) rather than their unsaturated analogues (4) showed better anti-bacterial (in vitro) activity against three human pathogens viz. Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli. In particular, three of them (3 b, 3 i &3 k) exhibited high inhibition against the growth of all the three pathogens comparable with that of the reference drug, tetracycline.
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| http://dx.doi.org/10.1016/j.bmcl.2014.09.027 | DOI Listing |
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